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Articles by Daniel Okin
NRF2 is a mechanosensitive checkpoint for NLRP3 inflammasome activation
Abstract Disconnects between in vitro and in vivo results in experimental biology have long been recognized as potential hurdles to understanding health and disease. A prototypical example of such a disconnect is the NLRP3 inflammasome, which mediates inflammation in diverse settings of disease and protective immunity1,2.
Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING
Keywords macrophage phagosome interferon toll-like receptor cGAS STING cyclic dinucleotides 2′3′-cUMP-AMP LRRC8A bacteria Introduction Central to the functions of innate immune pattern recognition receptors (PRRs) is their ability to bind microbial molecules known as pathogen-associated molecular patterns (PAMPs).
Regulation of inflammatory responses by pH-dependent transcriptional condensates
Keywords transcriptional condensates gene expression inflammatory response BRD4 pH acidosis histidine macrophage innate immunity IDR Introduction Inflammation is crucial for maintaining homeostasis and defending the integrity of tissues and organs.
Longitudinal multicompartment characterization of host-microbiota interactions in patients with acute respiratory failure - Nature Communications
Abstract Critical illness can significantly alter the composition and function of the human microbiome, but few studies have examined these changes over time. Here, we conduct a comprehensive analysis of the oral, lung, and gut microbiota in 479 mechanically ventilated patients (223 females, 256 males) with acute respiratory failure.
Improved survival in intubated patients with COVID-19 with longer prone positioning
Source/Disclosures Disclosures: Okin reports receiving support from NIH. Please see the study for all other study authors’ relevant financial disclosures. The editorial authors report no relevant financial disclosures. Source/Disclosures Disclosures: Okin reports receiving support from NIH. Please see the study for all other study authors’ relevant financial disclosures. The editorial authors report no relevant financial disclosures. We were unable to process your request. Please try again later.
The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia
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