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Articles by Daniel Strebinger
Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons - Nature Communications
Abstract R2 elements, a class of non-long terminal repeat (non-LTR) retrotransposons, have the potential to be harnessed for transgene insertion. However, efforts to achieve this are limited by our understanding of the retrotransposon mechanisms. Here, we structurally and biochemically characterize R2 from Taeniopygia guttata (R2Tg).
Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq - Nature Methods
Abstract Biomolecular condensates organize numerous subcellular processes and have been implicated in diseases, including neurodegeneration and cancer. Protein sequences intrinsically encode their propensity to form condensates, but specific sequence features that regulate this behavior have not been systematically explored at scale.
Evolution-guided protein design of IscB for persistent epigenome editing in vivo - Nature Biotechnology
Abstract Naturally existing enzymes have been adapted for a variety of molecular technologies, with enhancements or modifications to the enzymes introduced to improve the desired function; however, it is difficult to engineer variants with enhanced activity while maintaining specificity.
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins
Keywords CRISPR Cas13 RNA-guided mechanism toxin-antitoxin system bacterial immunity Introduction CRISPR-Cas systems are RNA-guided adaptive immune systems that guard bacteria and archaea against invading viruses and mobile genetic elements.
Cell type-specific delivery by modular envelope design - Nature Communications
Abstract The delivery of genetic cargo remains one of the largest obstacles to the successful translation of experimental therapies, in large part due to the absence of targetable delivery vectors. Enveloped delivery modalities use viral envelope proteins, which determine tropism and induce membrane fusion. Here we develop DIRECTED (Delivery to Intended REcipient Cells Through Envelope Design), a modular platform that consists of separate fusion and targeting components.
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