This article was reviewed by Felix Gussone, MD. Key Takeaways: There’s no evidence creatine directly increases testosterone levels. Creatine has been linked to other potential benefits for exercise performance, such as aiding strength, power, and muscle gain. Creatine is generally considered safe, but people with underlying kidney disease or other chronic medical conditions should talk to a doctor before taking it. Creatine is a popular supplement for improving athletic performance.