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Daniela Mittermüller on Muck Rack

Daniela Mittermüller

As seen in: The Journal of Clinical Investigation
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Articles

Regulatory T cells suppress the motility of cytotoxic T cells in Friend retrovirus-infected mice

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By JCI Insight, Lucas Otto, Zoe Long, Daniela Mittermüller
| The Journal of Clinical Investigation
Abstract Antiviral immunity often requires CD8+ cytotoxic T lymphocytes (CTLs) that actively migrate and search for virus-infected targets. Regulatory T cells (Tregs) have been shown to suppress CTL responses, but it is not known whether this is also mediated by effects on CTL motility. Here, we used intravital 2-photon microscopy in the Friend retrovirus (FV) mouse model to define the impact of Tregs on CTL motility throughout the course of acute infection.
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