A.K.E. declares the following competing interests: advisory board and honoraria from AbbVie, Astellas, Gilead, Servier, Jazz, Otsuka/Astex, and RACE Oncology; speaker fees from AbbVie, Otsuka/Astex, Astellas and Jazz; Research Funding from RACE oncology and Otsuka/Astex. N.A.B. receives research funding from Merck KGaA and Bristol Myers Squibb.