Dan Silver
London
Director of New Editorial Product Development @Telegraph. Ex-,@DailyMirror, @MirrorFootball, @NME Tech and videogames writer. Semi-professional West Ham fan.
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Articles by Dan Silver
Navigating Efficacy Benchmarks and Real-World Outcomes in Metastatic Colorectal Cancer
Patients with metastatic colorectal cancer (mCRC) who progress through 2 prior lines of therapy face a narrowing therapeutic window—and a growing body of evidence is helping nurses, advanced practice providers (APPs), and physician assistants (Pas) make better-informed decisions about which agents to reach for next.
FDA Approves Durvalumab and BCG for High-Risk NMIBC
In a significant development for the urologic oncology community, the U.S. Food and Drug Administration (FDA) has approved durvalumab (Imfinzi) in combination with Bacillus Calmette-Guerin (BCG) for the treatment of adult patients with BCG-naïve, high-risk non-muscle invasive bladder cancer (NMIBC). The approval provides a new therapeutic avenue for patients whose disease has not yet been treated with BCG and carries a high risk of progression.
Imetelstat Demonstrates Survival Benefit in R/R Myelofibrosis Vs Real-World Data
An updated post hoc analysis from the phase 2 IMbark trial (NCT02426086) has reaffirmed that imetelstat (Rytelo), a first-in-class telomerase inhibitor, delivers a clinically meaningful and statistically significant overall survival (OS) benefit compared with best available therapy (BAT) in patients with JAK inhibitor–relapsed or refractory (R/R) intermediate-2 or high-risk myelofibrosis (MF), with results to be presented at the 2026 ASCO Annual Meeting.
FDA Approves Pivekimab Sunirine-pvzy for BPDCN
The Food and Drug Administration (FDA) has announced the approval of pivekimab sunirine-pvzy (Decnupaz) for the treatment of adults with blastic plasmacytoid dendritic cell neoplasm (BPDCN). This new therapeutic option is a CD123-directed antibody and alkylating agent conjugate, specifically designed to target the unique markers of this ultra-rare hematologic malignancy.
Darolutamide Shows Less Cognitive Decline Vs Enzalutamide in Advanced Prostate Cancer
Darolutamide (Nubeqa) was associated with significantly less objectively assessed cognitive decline compared with enzalutamide (Xtandi) over 24 weeks, according to results from the prospective, randomized open-label phase 2 ARACOG trial (AFT-47; NCT04335682) to be presented at the 2026 ASCO Annual Meeting.
Treating Erectile Dysfunction Post-Prostate Cancer Therapy Requires Personalization
Erectile dysfunction (ED) is a frequent complication for patients with prostate cancer. During a presentation on “Men’s Health” at the 2026 Annual APP Symposium, hosted in Nashville, TN, Dan Silver, PA-C, an advanced practice provider specializing in ED, low testosterone, and Peyronie’s Disease, at Arizona Urology Specialists, discussed the diverse etiologies of treatment-induced ED and the importance of implementing early, individualized therapeutic regimens.
Dan Silver, PA-C
Professor Director, Basic Science and Research in Medical Oncology Leader, Molecular Oncology Regulation and Approaches Program Sidney Kimmel Cancer Center Articles by Dan Silver, PA-C Learn how prostate cancer treatments affect erections—and the tailored rehab options, from Cialis to pumps and injections, that restore intimacy.
A New Piece of the Puzzle of Covid’s Origin
Sign in or Subscribe Now for audio version Nearly seven years ago, the world was about to awaken to the fact that a novel pneumonia from Wuhan, China, was becoming the most disruptive global event in living memory. The intervening years have produced significant scientific understanding about this event, but not complete transparency. Key facts have surfaced slowly, and increasingly not at all, impeded by the passage of time and the protective layers of China’s bureaucracy.
When the City Won’t Be Quiet: Rethinking Sound in Public Places
SOUND OFF - Music has become an oppressor. What was once a wondrous gift of technology - the recording and reproduction of music – is now an invading force. Instead of listening on your own terms, intrusive loud music imposes itself nearly everywhere. It follows you into markets, drugstores, shops of all sizes and kinds, lobbies, and dental offices. It emanates from gasoline pumps and municipal lampposts. Instead of respecting personal space, no one asks if the music is wanted.
“We blew this whole scene open, I don’t care what anybody says. We did all the work, and now all these other bands are popping up”: How Korn changed up their sound and left the copycats behind with Follow The Leader | Flipboard
Elsa Dutton From Yellowstone Is Gorgeous In Real Life - Glam • Beauty • Celebrity Beauty From the modern-day bunkhouse of Dutton Ranch to the wilds of the 1880s, the "Yellowstone" universe has grown to encompass a …
How Korn changed up their sound and left the copycats behind with Follow The Leader
When you buy through links on our articles, Future and its syndication partners may earn a commission. Credit: Bob Berg/Getty Images Nu metal founding fathers Korn can legitimately lay claim to kickstarting a whole new scene with their landmark 1994 debut album, but follow up Life Is Peachy was a disappointment by contrast.
How Disturbed defied the odds to become nu metal superstars with The Sickness
When you buy through links on our articles, Future and its syndication partners may earn a commission. Credit: Mick Hutson/Redferns Disturbed emerged from the late 1990s nu metal scene to become breakout stars of the new millennium, thanks to the success of their debut album The Sickness. In November 2000, as the band prepared to play their debut UK show, Metal Hammer sat down with the Chicago band to talk success and the state of rock.
How Metallica kicked back against the 1990s haters with Reload
When you buy through links on our articles, Future and its syndication partners may earn a commission. Credit: Niels van Iperen/Getty Images Thanks to a shift in sound and image, Metallica’s mid-90s period was the most divisive era of their career to that point. But in this classic interview from the Metal Hammer archives, originally published on the eve of the release of 1997’s Reload album, we found drummer Lars Ulrich in defiant mood – and ready to push back against the haters.
Women footballers line up alongside men in new EA Sports FC videogame
Greet the new dawn, bub! For the first time in 30 years, EA Sports’ flagship football franchise kicks off a new season without the Fifa endorsement that had contributed not just to the videogame’s title, but also its identity. As such, ‘FC’ (as the publisher perhaps optimistically hopes it will come to be known by fans) arrives burdened with expectation – much of which is self-inflicted.
Rock star developers, low poly grapes, and clip-on cat ears: Inside the Final Fantasy XIV Fan Fest
Punters in Las Vegas will, by and large, gamble on anything – and yet even the most reckless would have hesitated to put money on Final Fantasy XIV even surviving to its 10th anniversary, let alone being able to mark the occasion with a lavish celebration for 15,000 of its most fervent fans in the party capital of the world.
After Fifa and EA Sports’ split - what is next for the future of football gaming?
Few commercial partnerships in global sport have been as long-lasting, influential, or, indeed, lucrative, as that between Fifa and video game publisher EA Sports. Their first collaboration, 1993’s Fifa International Soccer, timed to mark the following year’s US-hosted World Cup finals, and released on such long-gone gaming platforms as the Commodore Amiga, Sega Mega Drive, and the 3DO, was an unprecedented success, selling some 500,000 copies in the UK in its first month.
Dead Island 2 review: much-delayed zombie slasher sequel is a gonzo, gore-soaked gaming guilty pleasure
Dead Island 2's zombies come in all shapes and sizes, ranging from weedy runners to apex predator variants, like this crusher A decade is a long time in videogames so you could be more than forgiven for having forgotten about Dead Island 2 since it debuted at E3 way back in 2014.
Lords of the Fallen preview: meet the gorgeous Soulslike reboot hoping to be this year's Elden Ring
Lords of the Fallen looks genuinely spectacular thanks to to the next gen power of Unreal Engine 5 You could be forgiven for not remembering too much about Lords of the Fallen, a so-so Dark Souls knock-off released to middling reviews on last-gen consoles back in 2014.
Four Ways Ecommerce Brands can Overcome the Overstock of Excess Inventory
After three years of supply chain logistics and shipping delays, retailers have too much inventory sitting on shelves, and consumer demand continues to be in flux as inflation maintains a strong grip on budgets everywhere. This means the way consumers shop has drastically changed as new financing options rise in popularity. Buy Now, Pay Later (BNPL) vendors like Klarna and Afterpay are helping consumers ease the burden of inflation on their slimmed-down budgets.
PSVR2 games round-up: the best virtual reality experiences for PS5's next gen headset
The good news is that with over 30 titles available to play from day one, PSVR2 certainly doesn’t lack for software support. The not-so-good news is that bespoke blockbuster experiences like Horizon Call of the Mountain are the exception rather than the norm, and the bulk of that catalogue comprises ports of titles originally released for much less powerful machines.
Representation and global warfare: how real-world issues shaped the new Call of Duty campaign
Call of Duty Modern Warfare 2 “Ooh, a chicken and egg question!” cackles Brian Bloom, a likeable and loquacious New Yorker with a string of film, TV, and videogame credits on both sides of the screen that stretch all the way back to a bit part in Sergio Leone’s 1983 classic Once Upon a Time In America. He’s currently holed up in a former stock exchange in Amsterdam on a press junket for the latest Call of Duty instalment, Modern Warfare II, on which he served as lead writer.
Gotham Knights review: riddle me this - when is a Batman game not a Batman game?
Gotham Knights is not a Batman game. We know this because the Caped Crusader is killed – literally, terminally, inescapably – in its opening reel. The in-game pretext for this is a thematic exploration of heroic legacy and what it means to the people – good and bad – left behind. The real-world subtext is much simpler: you know those Arkham games you loved? Well, this ain’t one of them.
FIFA 23 review: long-running franchise bows out on a high with a little something for everyone
FIFA 23 is released for Xbox, PlayStation and PC on September 30 Shearer and Sutton. Keys and Gray. Allardyce and pints of wine. Football’s Premier League era has been shaped by all manner of game-changing double acts. By contrast, the last three decades on the virtual pitch have been ruled by just one particular pairing. EA Sports and FIFA’s 30-year partnership has generated hundreds of millions of videogame sales and tens of billions of dollars in revenue.
Metal: Hellsinger review - hard-rocking shooter hybrid proves hell ain't a bad place to be
Metal: Hellsinger – just in case you were wondering what it would be like to be trapped in the grooves of an '80s thrash metal album The best first person shooters have a natural groove to their gunplay; in Metal: Hellsinger, the groove is the gunplay.
The Last of Us Part 1 review: post-apocalyptic PS3 classic gets a next-gen glow-up - but at what price?
The Last of Us Part 1: Naughty Dog's 2013 masterpiece receives a next-gen glow up on PS5 Does the videogame industry have a problem with the repackaging and preservation of its past?
California Voice: Converting idle commercial land would ease state’s housing and climate crises
One of the most consequential housing bills before lawmakers this year — Assembly Bill 2011 — is designed to address California’s housing crisis by making it easier to convert unused commercial space into new homes. While the legislation focuses on housing strategies, it is also critically important environmental policy.
Converting idle commercial land would ease state’s housing and climate crises
Dan Silver and Amanda Brown Stevens CalMatters One of the most consequential housing bills before lawmakers this year — Assembly Bill 2011 — is designed to address California’s housing crisis by making it easier to convert unused commercial space into new homes. While the legislation focuses on housing strategies, it is also critically important environmental policy.
America's Hottest Zip Code Gets Almost Seven Feet of Snow a Year
Credit: The MIT Press, 2022. For Immediate Release " Tornado of Life is a tour de force. It features patient narratives, sketches of the ER, self-portraits of [Baruch's] development as a provider throughout [his] career, and [his] reflective and analytical essays on the multidirectional relationships between narrative and healthcare.
Low parent interest in COVID-recovery interventions should worry educators and policymakers alike
VANCOUVER - Ottawa's drug pricing changes may result in lower costs, but will also likely reduce Canadians' access to life-saving pharmaceuticals and potentially discourage investment in Canada's pharmaceutical sector, finds a new study released today by the Fraser Institute, an independent, non-partisan Canadian public policy think-tank.
FIFA 23 hands-on preview: focus on women's football makes final FIFA game the most inclusive ever
The fully-licensed Women's Super League makes its debut in FIFA 23 Ironically given its focus on cover superstars Kylian Mbappe and Sam Kerr, the person most brought to mind by EA Sports' two-hour FIFA 23 reveal was actually much maligned Manchester United stand-in/scapegoat, Ralf Rangnick.
'We're very encouraged by their vision': Chelsea Supporters' Trust member impressed by Todd Boehly
Chelsea Supporters’ Trust member Dan Silver tells Sportsmail how the group have been left ‘encouraged’ after holding talks with new owner Todd Boehly about the club’s future. Throughout the takeover process we met with several potential owners on a number of occasions including Todd Boehly and his representatives. We had very open conversations, they all met and listened to us and made some really positive noises. The Boehlys has been very engaging and hopefully that continues.
Elden Ring review: punishing open world take on the Dark Souls formula more than justifies the hype
Elden Ring: taking beauty and brutality to fantastic new extremes Roll. Backstep. Run backwards... Wait for the two storey-tall golden axe crashing down into the causeway, dislodging a lethal fan of flagstones and masonry. Once. Twice... Charge back in. Leap into a mid-air attack. Feel the blow land. Notice the boss's health bar has shrunk – not nearly enough but, still... Is there a chance to land another blow? A heartbeat's worth of indecision. Perhaps if I just… Swoosh. Slash. Flames.
Horizon Forbidden West review: machine-busting action RPG ramps up the scale for sprawling sequel
Horizon Forbidden West: still raging against the machines Difficult second album syndrome is a long-established concept in the music world, the theory running that while groundbreaking bands have their entire lifetimes to come up with that initial starburst of surefire self-expression and fresh takes on familiar themes, sending them back to the studio to recreate that alchemy to order can be another thing entirely.
Support for Mask and Vaccine Policies in Schools Falls along Racial and Political Lines
As COVID-19 rates rise again with the emergence of the omicron variant and roil school reopening plans, local educational leaders are faced with tough decisions about school policies. Though arguably these decisions should be informed by science, administrators must also consider how parents will respond.
Are fiery school-board meetings representative of all parents?
By Anna Saavedra, Amie Rapaport, Morgan Polikoff, Dan Silver The pandemic has challenged public education in a variety of ways. School leaders, teachers, families, and students are contending with controversies over vaccines, mask-wearing, quarantine procedures, and the ever-present threat of new variants, to say nothing of students’ academic and social-emotional setbacks.
Call of Duty Vanguard review: shooter series returns to its roots for World War II greatest hits tour
Call of Duty Vanguard The days when new Call of Duty games landed like cultural hand grenades whose shockwaves could be measured in ringing cash registers and outraged tabloid typefaces feel long gone. The seminal series’ star attraction is now by some distance its free-to-play battle royal behemoth Warzone; the still yearly interstitial standalone shooters have become very much victims of that persistent, free-to-play mode’s stratospheric success.
Telegraph creates new scoring metric for audience engagement and retention
When used properly, metrics are powerful tools for helping editorial staff make the decisions that will ultimately achieve critical business objectives. At The Telegraph, that means hitting CEO Nick Hugh’s publicly stated target of 1 million paying subscribers from a pool of 10 million registered users by the end of 2023. When not used properly, however, bad metrics lead to bad decisions. When I first arrived at The Telegraph in 2017, the KPI used in the newsroom was pageviews.
Starfield director Todd Howard exclusive: I want everybody to be able to play my games in some fashion
Starfield: launching exclusively on PCs and Microsoft's next gen consoles in 2022 Xbox's E3 2021 showcase pulled back a little more of the curtain on Starfield, the sprawling new space epic being developed by RPG masters Bethesda Games Studios.
Issue 24 Archives | The Point Magazine
Spring 2021 The annotated table of contents below offers a sneak peek at what's in Issue 24. Buy Now No Good Has Come By Elisa Gonzalez Marilynne Robinson has called writing a “testimony.” For her work—six books of dense and fiery nonfiction, and five novels—“testimony” is a suitably multifarious word. It […] House Hunters By Nora Caplan-Bricker I wondered if these novels could cut through it to show me whether there is, in fact, anything suspect about the longing for a house.
The best PS5 games: From Demon's Souls to Spider-Man, what you need to play on your new PlayStation 5
Marvel's Spider-Man: Miles Morales brings the next gen goodness The PS5 finally launches in the UK on November 19th - and thanks to backwards compatibility there are literally thousands of games available to play on it from day one. Most new console owners will be looking for native next-gen experiences to show off their new hardware, however.
Call of Duty: Black Ops Cold War review: 80's-themed shooter is a throwback in all senses
South China Morning Post Outgoing US Justice Department officials call their ‘China Initiative’ to counter Beijing a success The US Justice Department gave itself high marks in a report card released on Monday on the second anniversary of its “China Initiative”, a programme aimed at blunting Beijing’s influence in the United States.The assessment, released as a new administration prepares to take power, comes as more Republican voices try to nudge President Donald Trump into acknowledging his...
The West Ham Podcast: Manny Happy Returns on Apple Podcasts
57 min Phil Whelans and Jim Grant are joined by Dan Silver for this week’s show. westhampodcast.com @westhampodcast Produced by Paul Myers and Mike Leigh Engineered by Leon Gorman A Playback Media Production playbackmedia.co.uk Copyright 2020 Playback Media Ltd - playbackmedia.co.uk/copyright 57 min
FIFA 21 review: the more things change, the more they stay the same
Unusually for a franchise obsessed with pixel perfect photo realism and expensively acquired authenticity, FIFA’s latest instalment feels like an escapist fantasy every bit as otherworldly as Call of Duty or Cyberpunk 2077. With sometimes surprisingly jarring dissonance, FIFA 21 explodes into football’s desolate Covid landscape like a neon confetti cannon.
Hades review: a devilishly good time
Hades review - Supergiant Einstein famously defined insanity as doing the same thing again and again but expecting a different result each time. Quite would he made of ‘roguelikes', then, is anybody’s guess. The increasingly popular - and prevalent - game design trope tasks players with repeating procedurally-generated ‘runs’ ad infinitum, usually with character progress or resources carried over to increase incrementally the chance of success on each subsequent attempt.
Ghost of Tsushima review: a beautiful but banal samurai crusade
Ghost of Tsushima: all filler, no killer It doesn’t require a military strategist of the caliber of Sun Tzu to discern that one of Sony’s most successful tactics in this generation’s great console war has been their commitment to exclusive games. Indeed, Microsoft’s increasingly forced attempts to focus attention onto tech specs can be read as an attempt to deflect from years of neglecting their first party development studios.
PS5 launch: Plenty of promise, but questions still hang over Sony's new console
Video game console launches are traditionally grandstanding affairs, held in grand ballrooms or cavernous conference centres in which the great and the good of the gaming community gather to genuflect before a black box slightly bigger than the one which came before it. Sony’s first proper public unveiling of the PlayStation 5, the logically if unimaginatively named successor to the 100 million-selling PlayStation 4, was none of those things.
Final Fantasy 7 Remake review: a breathtaking but bloated retread of a classic
Final Fantasy 7 remake - Square Enix Despite being decorated for single-handedly breaking the Japanese role playing game genre in the West, Final Fantasy 7 was also maligned for many years as the videogame most returned to vendors by disgruntled customers. The story went that American gamers seduced by its stunning CG cutscenes and hysterical notices were subsequently baffled and, worse, bored by its complex mechanics and uniquely oriental approach to storytelling.
Boredom | The Point Magazine
If you have spent any significant amount of time in some kind of creative endeavor you have probably also spent a lot of time being bored. Your day tends to be unstructured and open, leaving room to do nothing that goes nowhere. You likely live with a generalized hope for moments of peak experience, which makes the rest of life into a desert of normalcy and routine. The purpose of any creative project is inherently uncertain.
Half-life: Alyx review: Valve's classic series provides VR's killer app
The hysteria generated by last year’s surprise announcement heralding the return of the genre-defining but long-presumed killed-in-action shooter series Half-Life was quickly tempered by news it would do so exclusively in virtual reality.
California's Wildfire Suppression Effort Won’t Prevent Catastrophic Fires
By Dan Silver, Executive Director of the Endangered Habitat League. A wildfire suppression plan adopted at the end of 2019 by the California Board of Forestry could cost taxpayers hundreds of millions of dollars but will do very little to actually reduce fire risk for communities in Sonoma County and throughout the state. Fire safety experts and environmental protection advocates filed suit on January 28 to block the new Vegetation Treatment Program (VTP) from going into effect.
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