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Articles by Daqi Wang
Re-administration of AAV-mediated gene therapy for OTOF -related deafness: a single-arm trial
Abstract Re-administration of adeno-associated virus (AAV)-mediated gene therapy remains challenging due to neutralizing antibodies (NAbs) induced by the initial dose. We previously conducted a single-arm trial showing that single-dose administration of AAV-hOTOF gene therapy in individuals with OTOF-related deafness is safe and leads to hearing improvements.
Multicentre gene therapy for OTOF -related deafness followed up to 2.5 years
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Abstract Autosomal recessive deafness 9, caused by OTOF gene mutations, is characterized by severe-to-complete congenital deafness1. Although gene therapy has shown benefits in a small number of patients2,3,4,5, its safety and efficacy across broader age ranges and longer follow-up periods, as well as predictors of treatment outcomes, remain unclear.
By Xiaoting Cheng, Jun Lv, Yuxin Chen, Xiaoyun Chen, Rongqun Zhai, Liqin Zhang, Yiling Zhang, Juhong Zhang, Di Deng, Zhicheng Huang, Qi Cao, Xin Zhang, Daqi Wang, Yizhe Wang, Liheng Chen, Sha Yu Verified, Luo Guo, Bowen Zhang, Hui Wang, Yi Zhou, Liling Dai, Wei Wang, Longlong Zhang, Yanbo Yin, Guiqing Cheng, Ziyi Zhou, Wuqing Wang, Bing Chen, Wei Lu, Zhiqiang Gao, Dazhi Shi, Yuanping Xiong, Yu Zhao, Wei Yuan, Qin Wang, Guodong Feng, Huawei Li, Zheng-Yi Chen, Yilai Shu, Luoying Jiang, Hongqun Jiang
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Nature
Verified
BEdeepon: an in silico tool for prediction of base editor efficiencies and outcomes
Abstract Base editors enable direct conversion of one target base into another in a programmable manner, but conversion efficiencies vary dramatically among different targets. Here, we performed a high-throughput gRNA-target library screening to measure conversion efficiencies and outcome product frequencies at integrated genomic targets and obtained datasets of 60,615 and 73,303 targets for ABE and CBE, respectively.
Inner ear therapeutics and the war on hearing loss: systemic barriers to success
Introduction Hearing loss is one of the most common treatable health conditions in the world. It is a problem with profound economic and social impact. The World Health Organization completed and released results of an extensive study of the problem in 2021 (Olusanya et al., 2019; Deafness and hearing loss [Internet], 2023). The causes of hearing loss, the societal impact, and the potential remedies vary between the developed and developing world.
Newborn hearing screening program in China: a narrative review of the issues in screening and management
1. Introduction Hearing loss is one of the most common congenital disabilities worldwide. The World Report on Hearing published by the World Health Organization (WHO) indicates that >1.5 billion people currently experience some degree of hearing loss, a number that could grow to 2.5 billion by 2050 (1). The WHO estimates that more than 400 million people, including 34 million children, live with disabling hearing loss, which affects their health and quality of life (1).
Approaches and Vectors for Efficient Cochlear Gene Transfer in Adult Mouse Models
Open AccessArticle by Yu Zhao 1,2,3,†, Longlong Zhang 1,2,3,†, Daqi Wang 1,2,3, Bing Chen 1,2,3,* and Yilai Shu 1,2,3,* 1 ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China 2 Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China 3 NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 200031, China * Authors...
Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing
Xi Gu1,2,3,4 na1, Daqi Wang1,2,4 na1, Zhijiao Xu1,2,4 na1, Jinghan Wang1,2,4, Luo Guo1,2,4, Renjie Chai5,6,7, Genglin Li1,2,4, Yilai Shu ORCID: orcid.org/0000-0001-8893-434X1,2,4 na2 & Huawei Li1,2,4,8 na2 Genome Biology volume 22, Article number: 86 (2021) Cite this article Abstract Background Aging, noise, infection, and ototoxic drugs are the major causes of human acquired sensorineural hearing loss, but treatment options are limited.
Author Correction: An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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