Wei Lu on Muck Rack

Wei Lu

As seen in: Medium, MSN, National Institutes of Health, Arthritis & Rheumatology, Bloomberg Businessweek, Bloomberg Markets Magazine, Bloomberg News, British Ecological Society (Wiley), British Journal of Cancer, Business Insider and
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Articles

A pilot translational study of neoadjuvant fulvestrant plus abemaciclib in women with advanced low-grade serous carcinoma

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By Lauren Cobb, Yibo Dai, Max Ayala, Nejla Ozirmak Lermi, Sharia Hernandez, Joseph Davis Verified, SangHoon Lee, Richard Hajek, Joseph Celestino, Jinsong Liu, Linghua Wang, Cara Haymaker, Ken Chen, Mei Jiang, Wei Lu, Minghao Dang, Sara Hagen Hull, David Vining, Bryan M. Fellman, Ying Yuan, Anil K Sood, Shannon N. Westin, Jolyn S. Taylor, Aaron Shafer, Nicole Fleming, Karen H. Lu, David M. Gershenson, Amir A Jazaeri, Barrett Craig Lawson, Beatriz Sanchez-Espiridion, Michael Bevers
| Nature Verified
Abstract Low-grade serous carcinoma of the ovary (LGSOC) is relatively resistant to chemotherapy. Given its biological parallels to hormone receptor-positive breast cancer, including responsiveness to anti-estrogen therapies, we conducted a pilot phase II study to assess clinical benefit of neoadjuvant fulvestrant and abemaciclib in women with advanced, unresectable LGSOC (NCT03531645). Imaging assessments were performed every 8 weeks until resectable.
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Single-cell and experimental analyses identify mitochondria-related genes Hmgcs2, Nudt5, and Cpt1c in painful diabetic peripheral neuropathy

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By Jiaqi Cao, Zhongjie Zhang, Yu Chen, Xiaoyi Yu, Xuan Xiang, Wei Lu
| Nature Verified
Abstract Painful diabetic peripheral neuropathy (PDPN) is a multifactorial disabling complication of diabetes, yet the pathogenesis involving mitochondrial dysfunction in immune cells remains unclear. This study aimed to identify mitochondria-related genes (MRGs) in PDPN and explore their biological relevance. Based on single-cell transcriptomic analysis, we identified three key MRGs (Hmgcs2, Nudt5, and Cpt1c) shared across two independent datasets and validated them in rat PDPN models.
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Bilateral cerebellar intermittent theta-burst stimulation combined with laryngeal elevation training promotes neurorestoration in post-stroke dysphagia

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By Haiquan Zhang, Di Zhang, Wei Lu, Min Liu, ShanShan Wang, Shanshan Wang
| Nature Verified
Abstract Previous studies have shown that pharyngeal elevation training can improve swallowing function in stroke patients, but the central nervous system interventions have limited effects. Intermittent theta burst stimulation (iTBS) applied to bilateral cerebellar hemispheres may enhance cortical excitability.
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