Darcie Moore on Muck Rack

Darcie Moore

Brunswick
As seen in: Nature, PLOS Biology, Frontiers, Bangor Daily News, The Portland Press Herald, The Times Record, Sun Journal (Lewiston, ME), Kennebec Journal, Morning Sentinel, Journal Tribune and
Senior reporter at The Times Record
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Articles

Harnessing the stem cell potential in the human hippocampus to limit cognitive aging

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By Susmit Mhatre, Darcie Moore
| PLOS Biology
Cognitive decline is an unwelcome part of "normal" aging. Memory fades gradually: forgetting why we went to the refrigerator or leaving the dog outside, calling family members by other names. We begin to ask ourselves: are these the first steps towards losing the memories of a well-lived life—and what, if anything, can we do? In rodents, new neurons can still be produced in adults in the brain region important for learning and memory, the hippocampus.
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Neuron-specific isoform of PGC-1α regulates neuronal metabolism and brain aging - Nature Communications

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By Kevin W. Eliceiri, Darcie Moore, Luigi Puglielli
| Nature
Abstract The brain is a high-energy tissue, and although aging is associated with dysfunctional inflammatory and neuron-specific functional pathways, a direct connection to metabolism is not established. Here, we show that isoforms of mitochondrial regulator PGC-1α are driven from distinct brain cell-type specific promotors, repressed with aging, and integral in coordinating metabolism and growth signaling.
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Transcript errors generate amyloid-like proteins in huwman cells - Nature Communications

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By Max A. Thorwald, Renaldo G. Toney, Yuxin Jin, Darcie Moore, Kelley Thomas, Marcelo P. Coba, Zhongwei Li, Bérénice A. Benayoun, Scott Kennedy, Giorgia Quadrato, Lin Chen
| Nature
Abstract Aging is characterized by the accumulation of proteins that display amyloid-like behavior. However, the molecular mechanisms by which these proteins arise remain unclear. Here, we demonstrate that amyloid-like proteins are produced in a variety of human cell types, including stem cells, brain organoids and fully differentiated neurons by mistakes that occur in messenger RNA molecules.
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