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Dasa Bohaciakova

As seen in: Nature, BioRxiv
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Articles

A model of human neural networks reveals NPTX2 pathology in ALS and FTLD - Nature

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By Marian Hruska-Plochan, Vera I. Wiersma, Katharina M. Betz, Elena Tantardini, Florent Laferrière, Igor Delvendahl, Manuela Pérez-Berlanga, Dasa Bohaciakova, Puneet Sharma, Laura De Vos, Karl Frontzek, Adriano Aguzzi, Tammaryn Lashley, Theofanis Karayannis, Martin J. Mueller, Andreas Hierlemann, Izaskun Mallona
| Nature Verified
Abstract Human cellular models of neurodegeneration require reproducibility and longevity, which is necessary for simulating age-dependent diseases. Such systems are particularly needed for TDP-43 proteinopathies1, which involve human-specific mechanisms2,3,4,5 that cannot be directly studied in animal models.
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Apolipoprotein-based regulation of ganglioside metabolism upon secretase activity inhibition in iPSC-derived cerebral organoids

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By Durga Jha, Tereza Vanova, Dasa Bohaciakova, Zdenek Spacil
| BioRxiv
Abstract Beta and gamma-secretase inhibitors have been of pharmacological interest to reduce abeta (Aβ) formation and aggregation, a defining characteristic of Alzheimer's disease (AD). Recent research indicates that Apolipoprotein E (ApoE), another genetic risk factor for AD, can regulate secretase activity. Secretase inhibitor-induced elevation of neuronal membrane lipids has been documented in 2D models.
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Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells

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By Qi Ma, Angels Almenar-Queralt, Bridget Kohlnhofer, Dasa Bohaciakova
| Nature Verified
Abstract In the mammalian genome, the clustered protocadherin (cPCDH) locus provides a paradigm for stochastic gene expression with the potential to generate a unique cPCDH combination in every neuron. Here we report a chromatin-based mechanism that emerges during the transition from the naive to the primed states of cell pluripotency and reduces, by orders of magnitude, the combinatorial potential in the human cPCDH locus.
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