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David Akbar

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Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels

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By Myriam Spajer, Kurt A. Sailor, Laura Sheridan Mouton, Diana Doukhi, Sunil Koundal, Kevin Boyé, Felipe Saceanu Leser, Han Xu, Jérôme Van Wassenhove, Anthony J. Ruze, Marie-Charlotte Bourrienne, Young-Kwon Hong, Mikael Mazighi, Pierre-Marie Lledo, Helene Benveniste, Mathieu David Santin, Anne Eichmann, Stéphane Lehéricy, Jean-Leon Thomas, Stephanie Lenck, Marie-Renee El Kamouh, Ruchith Singhabahu, Anne-Laure Joly Marolany, Tanner Metcalfe, Dominique Langui, Abel Grine, Justus Ninnemann, Joshua Gottschalk, Cyrus Sadeghi, David Akbar, Amelle Nasri, Elora Buscher
| Nature Verified
Abstract Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure and dural venous sinus stenoses, which can be relieved by venous stenting. Here we investigated whether venous blood flow may play a role in controlling brain pressure. Using magnetic resonance imaging in patients with IIH and healthy controls, we identified that dural venous stenoses in IIH were associated with alterations of the perivenous fluid pattern and brain edema.
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