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Pierre-Marie Lledo on Muck Rack

Pierre-Marie Lledo

As seen in: Nature, Ouest France, The Conversation, Les Échos, Cell Reports, Physician's Weekly, Cerveau & Psycho
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Articles

Vagal subcircuits differentially regulate sepsis-induced sickness and anxiety-related behaviors

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By Lena Bourhy, Carine Moigneu, Alice Dupin, Jarod Lévy, Pierre-Marie Lledo, Tarek Sharshar, Gabriel Lepousez, Esteban Delelis
| Cell Reports Verified
Keywords neuroinflammation neuro-immune interactions cecal ligation and puncture pharmacogenetics vagotomy fear conditioning nucleus of the tractus solitarius extended amygdala dorsal vagal complex anxiety Research topic(s) CP: neuroscience Introduction The immune and nervous systems interact extensively in both health and disease.1 The brain continuously monitors the state of the immune system through a process known as immunoception.2 By integrating internal and environmental stimuli,...
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Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels

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By Myriam Spajer, Kurt A. Sailor, Laura Sheridan Mouton, Diana Doukhi, Sunil Koundal, Kevin Boyé, Felipe Saceanu Leser, Han Xu, Jérôme Van Wassenhove, Anthony J. Ruze, Marie-Charlotte Bourrienne, Young-Kwon Hong, Mikael Mazighi, Pierre-Marie Lledo, Helene Benveniste, Mathieu David Santin, Anne Eichmann, Stéphane Lehéricy, Jean-Leon Thomas, Stephanie Lenck, Marie-Renee El Kamouh, Ruchith Singhabahu, Anne-Laure Joly Marolany, Tanner Metcalfe, Dominique Langui, Abel Grine, Justus Ninnemann, Joshua Gottschalk, Cyrus Sadeghi, David Akbar, Amelle Nasri, Elora Buscher
| Nature Verified
Abstract Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure and dural venous sinus stenoses, which can be relieved by venous stenting. Here we investigated whether venous blood flow may play a role in controlling brain pressure. Using magnetic resonance imaging in patients with IIH and healthy controls, we identified that dural venous stenoses in IIH were associated with alterations of the perivenous fluid pattern and brain edema.
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Neither alive nor dead: disembodied human brains put to use in medicine

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By Pierre-Marie Lledo
| polytechnique-insights.com
By restoring certain functions of intact brains taken from deceased donors, the start-up Bexorg hopes to create a more accurate experimental environment for the development of drugs to treat neurodegenerative diseases. Only yesterday, this brain was part of a living being.
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