David Armand Fidock on Muck Rack

David Armand Fidock

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Articles

Identification of genetic markers of quinine partial resistance in Plasmodium falciparum

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By Mariko Kanai, Sachel Mok, Tomas Yeo, Melanie J. Shears, Jin Jeon, Sunil K Narwal, Leila S Ross, Kharizta Wiradiputri, Meseret T. Haile, Abhai Tripathi, Godfree Mlambo, Jonathan Kim, Eva Gil-Iturbe, Heekuk Park, Tolla Ndiaye, John Okombo, Kurt E. Ward, Felix Rozenberg, Kate Fairhurst, Jessica L. Bridgford, Tanaya Sheth, Manuel Llinás, Marcus Lee, Jennifer L. Small-Saunders, Filippo Mancia, Matthias Quick, Anne-Catrin Uhlemann, Photini Sinnis, Sydney M. Gavula, Talia S. Bloxham, David Armand Fidock
| Nature Verified
Abstract The genetic basis of Plasmodium falciparum resistance to quinine, a drug used to treat severe malaria, has long been unclear. To investigate this, here we used a human liver-chimaeric mouse model to conduct a P. falciparum genetic cross between quinine-partially resistant and quinine-sensitive parasites. Drug profiling and quantitative trait loci analyses of 120 unique recombinant progeny mapped resistance to segments on chromosomes 7 and 12, indicating a polygenic basis.
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