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Abstract The genetic basis of Plasmodium falciparum resistance to quinine, a drug used to treat severe malaria, has long been unclear. To investigate this, here we used a human liver-chimaeric mouse model to conduct a P. falciparum genetic cross between quinine-partially resistant and quinine-sensitive parasites. Drug profiling and quantitative trait loci analyses of 120 unique recombinant progeny mapped resistance to segments on chromosomes 7 and 12, indicating a polygenic basis.
ArticleVolume 45, Issue 7117664Open access Affiliations & Notes 1Division of Biological Sciences, University of California, La Jolla, San Diego, CA, USA 2Department of Pediatrics, University of California, San Diego, San Diego School of Medicine, La Jolla, San Diego, CA, USA 3Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA 4Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA 5Department of Microbiology...
Materials and methods Parasites were cultured in fresh human erythrocytes obtained with ethical approval from anonymous healthy donors, with informed written consent as part of the recruitment process, from the National Health Services Blood and Transplant (NHSBT) or the Scottish National Blood Transfusion Service (SNBTS).
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