David Barinberg

Abstract Eosinophils exert antimicrobial, cytotoxic and immunoregulatory effects, but their function in cutaneous tissue still remains poorly understood. Here, we used a mouse model of chronic cutaneous leishmaniasis caused by the protozoan parasite Leishmania (L.) mexicana to investigate the function and transcriptomic signature of eosinophils in the skin. In C57BL/6 wild-type mice, L.

Keywords Leishmania parasites leishmaniasis immunity micro milieu factors persistence evasion Leishmania parasite infection cycle and leishmaniasis Leishmania is a protozoan parasite discovered at the end of the 19th and beginning of the 20th century in the skin or spleen of infected patients with oriental sores or kala-azar (see Glossary), respectively [1].