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David Barr

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Articles

Mycobacterium tuberculosis pathogen load and associated inflammatory responses define infection severity in HIV-associated TB and interact with age to predict mortality

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By Linda Boloko, Charlotte Schutz, Amy Ward, Robert Wilkinson, Shevin T Jacob, Graeme Meintjes, David Barr
| Journal of Infection Verified
Keywords Sepsis host response tuberculosis HIV bacteraemia mycobacteraemia Introduction Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.1 In practice, this is operationalized through clinical scoring systems used to risk-stratify patients, and the predictive accuracy of these scores for mortality is used to implicitly validate sepsis definitions.1 Despite the pragmatism underpinning sepsis definitions, longstanding controversy...
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Pender Global Small/Mid Cap Equity Fund - April 2026

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By David Barr
| PenderFund
The Pender Global Small/Mid Cap Equity Fund returned 6.3%1 in April. Following a pullback of 9.10% from its January high through late March, the S&P 500 rebounded to post a gain of 7.9% for the month and briefly touched new all-time highs.
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Pender Partners Fund - Q1 2026

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By David Barr
| PenderFund
The Fund returned 2.1%1 in Q1 against one of the more disorienting macro backdrops in recent memory. The Iran conflict escalated into a full-scale confrontation, and the effective blockade of the Strait of Hormuz sent shockwaves well beyond oil markets, disrupting fertilizer supply, broader commodity chains, and global trade flows in ways that are still being fully understood. US oil prices approached record highs before pulling back late in the quarter on hopes that a resolution may be near.
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