David Barr
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Articles by David Barr
Mycobacterium tuberculosis pathogen load and associated inflammatory responses define infection severity in HIV-associated TB and interact with age to predict mortality
Keywords Sepsis host response tuberculosis HIV bacteraemia mycobacteraemia Introduction Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.1 In practice, this is operationalized through clinical scoring systems used to risk-stratify patients, and the predictive accuracy of these scores for mortality is used to implicitly validate sepsis definitions.1 Despite the pragmatism underpinning sepsis definitions, longstanding controversy...
Pender Global Small/Mid Cap Equity Fund - April 2026
The Pender Global Small/Mid Cap Equity Fund returned 6.3%1 in April. Following a pullback of 9.10% from its January high through late March, the S&P 500 rebounded to post a gain of 7.9% for the month and briefly touched new all-time highs.
Pender Partners Fund - Q1 2026
The Fund returned 2.1%1 in Q1 against one of the more disorienting macro backdrops in recent memory. The Iran conflict escalated into a full-scale confrontation, and the effective blockade of the Strait of Hormuz sent shockwaves well beyond oil markets, disrupting fertilizer supply, broader commodity chains, and global trade flows in ways that are still being fully understood. US oil prices approached record highs before pulling back late in the quarter on hopes that a resolution may be near.
Pender Small Cap Opportunities Fund - Q1 2026
Markets were volatile this quarter, with small-cap technology in Canada bearing the brunt of the pressure. The S&P/TSX Info-T had one of its worst starts in recent history, driven by intensifying fears of AI-driven disruption and the so-called "SaaS-Pocalypse," even as the S&P/TSX Composite Index reached historic highs near 34,5001.
Pender Global Small/Mid Cap Equity Fund - March 2026
The first quarter of 2026 was marked by significant volatility that continues to reverberate across global markets. The backdrop has been characterized by pronounced dispersion across equity sectors and individual stocks. The global economy entered 2026 following a 2025 "soft landing" supported by AI spending and fiscal stimulus, but Q1 brought heightened geopolitical risks alongside growing fears that AI spending plans may be unsustainable.
Horticultural intensification and plant-based diets of 18 th century CE Waikato Māori in Aotearoa New Zealand
Abstract In Aotearoa New Zealand, Māori oral histories, ethno-historical accounts, and archaeological evidence indicate that kūmara (sweet potato; Ipomoea batatas) and taro (Colocasia esculenta) horticulture were key drivers of population growth and cultural change.
Additional Indictments Handed Down to Delhi Man
More indictments have been brought against a Delhi man who has previously been indicted on various sex charges. According to the Delaware County District Attorney, David W. Gensler has been indicted on the charges of Bribing a Witness and Criminal Contempt in the 2nd degree. He's accused of attempting to pay a witness from a previous indictment not to testify against him in court.
Pender Global Small/Mid Cap Equity Fund - February 2026
February was an interesting month for investors, marked by elevated volatility and significant return dispersion beneath relatively modest headline index moves. Market leadership continued to shift, and with geopolitical tensions rising into early March, volatility may remain a key dynamic as geopolitical tensions contribute to elevated global uncertainty. Portfolio weights remained approximately 56.7% Canadian equities and 42.2% US equities.
The lure of calendar patterns
Market lore and reality January is always an interesting time of year. Calendars are flipped, resolutions are made, and investors look for signals about what the year ahead may hold. But does a new year truly represent a fresh start for markets, or simply a continuation of existing trends? Many investors pay close attention to January as a potential leading indicator for the year. The so-called January Barometer suggests that as goes January, so goes the year.
Pender Partners Fund - January 2026
The Pender Partners Fund returned 7.0% in January. The Fund’s all-cap mandate provides flexibility to pursue mispriced opportunities across market segments and geographies. January is always an interesting time of year. Calendars are flipped, resolutions are made, and investors look for signals about what the year ahead may hold. But does a new year truly represent a fresh start for markets, or simply a continuation of existing trends?
Pender Partners Fund - December 2025
The Pender Partners Fund returned 2.1% in December, bringing YTD performance to +4.3%1. The Fund’s all-cap mandate provides flexibility to pursue mispriced opportunities across market segments and geographies. While broader market conditions appeared relatively stable, performance dispersion remained elevated, with returns driven by a narrow set of market leaders. In this environment, dispersion weighed on the Fund’s results.
Pender Global Small/Mid Cap Equity Fund - December 2025
As the curtain falls upon 2025, markets bow following their final act—with the assurance that, no matter how winding the plot, our revels now are ended. The year unfolded largely as optimists had hoped. Expectations were surpassed, resilience was tested and proven, and investors were broadly rewarded. Yet in such moments, the desire for an encore grows loud—one more act before the lights are dimmed and the stage is cleared.
Pender Small Cap Opportunities Fund - December 2025
As we begin 2026, it is worth reflecting on the forces that shaped markets over the past year. Resilience emerged as the defining theme, with equities largely shrugging off ongoing geopolitical and economic uncertainty. In many ways, 2025 felt like a long ski day with constantly changing conditions — smooth, packed powder one run, followed by unexpected ice and moguls the next. Early in the year, conditions were challenging.
Small-caps poised for above-average returns in 2026
Historically low valuations a springboard for rebound In November, the S&P/TSX Composite Index advanced, reaching a new record high. In commodity markets, gold prices rose, and silver also hit an all-time high, making Materials one of the month’s strongest-performing sectors, alongside Consumer Staples.
Pender Global Small/Mid Cap Equity Fund - November 2025
As we find ourselves in December, with the holiday season upon us, the question naturally arises: Do you believe in the Santa Rally? This seasonal phenomenon, where equities tend to rise in the run-up to Christmas, is one of the market’s most enduring traditions. Across geographies and market cycles, the pattern persists: according to recent analysis the FTSE 100 has delivered a positive December return in 24 of the past 30 years, while the S&P 500 has risen 22 times.
Pender Small Cap Opportunities Fund - November 2025
In November, the S&P/TSX Composite Index advanced, reaching a new record high. In commodity markets, gold prices rose, and silver also hit an all-time high, making Materials one of the month’s strongest-performing sectors, alongside Consumer Staples. A major development during the month was Prime Minister Mark Carney’s first federal budget, which outlined new spending aimed at strengthening Canada’s economic competitiveness, reducing reliance on US trade, and meeting defence commitments to NATO.
Every Thriving Business Owner Must Go Through the 'Hell Zone'
This story appears in the November 2025 issue of Entrepreneur. Subscribe » There’s a magical stage of growth that every franchisee dreams of reaching. It’s the point where your business has enough scale and momentum to run without your hand on the wheel every minute of the day. Finally, you get to sit back and enjoy the ride. Unfortunately, between the comfort of your first successful location and the stability of true scale, there lies a brutal and unglamorous stretch of growth.
Pender Partners Fund - October 2025
The Pender Partners Fund gained 1.5% in October and 4.5% YTD. The Fund’s all-cap mandate provides the flexibility to capture opportunities across market segments and geographies. As of quarter end, the portfolio comprised of 35 holdings with a 44.8% exposure to US equities and 42.1% exposure to Canadian equities. Top holdings are within Industrials, Technology and Financial Services which together account for nearly 50% of sector exposure.
Pender Global Small/Mid Cap Equity Fund - October 2025
As we enter the final two months of the year, there has been no shortage of excitement for investors. The month began with a US government shutdown, which has now ended after becoming the longest in history at 43 days. Despite this headline risk, corporate earnings have been robust — with 64% of S&P 500 companies having reported Q3 2025 results, showing year-over-year earnings growth of +10.7%, well above the expected +7.9%.
Pender Small Cap Opportunities Fund - October 2025
Equity markets continued to advance in October, though gains moderated as investors assessed a busy earnings season amid ongoing macroeconomic uncertainty. The Canadian economy continues to lose momentum, weighed down by trade frictions with the United States. Inflation edged higher during the month, while labour market indicators showed further signs of cooling. In response, the Bank of Canada lowered its benchmark overnight rate by 25 basis points to 2.25% at its October meeting.
Pender Small Cap Opportunities Fund - September 2025
September was another positive month for equities, with markets pushing to record highs despite ongoing macro uncertainty. In Canada, both the TSX Composite and TSX Small Cap Index reached new highs, while US small caps joined the rally with the Russell 2000 up 4.5% in September. US small caps gained ~15% (CAD) in Q3 vs. large caps at ~10.5% —supported by real earnings growth after a year of solid performance, expectations of rate cuts and attractive relative valuations.
AI and Enablement After Amgen v. Sanofi: Implications for Life Sciences Patents | JD Supra
The Supreme Court's Amgen Decision: A Narrowing of Enablement for Genus Claims The Supreme Court in Amgen v. Sanofi affirmed the invalidation of Amgen's antibody patents for lack of enablement. The patents at issue claimed "the entire genus" of antibodies capable of (1) binding specific amino acid residues on PCSK9 and (2) blocking PCSK9 from binding to LDL receptors.
Peace Walk Aims to Bring People Together
People from all walks of religion are welcome to attend a Peace Walk offered on August 24th. The event will begin at 6:30 p.m. with prayers and mediations regarding peace at the south pavilion in Otsiningo Park. Following the prayers and meditations, attendees will walk around the park at their own pace for approximately an hour. This walk is hosted by the Broome County Interfaith Council (formerly Children of Abraham).
Patent Term Adjustment and Double Patenting After In re Cellect
ODP, PTA, and PTE Federal Circuit’s ODP Analysis in In re Cellect District Court Decisions Interpreting In re Cellect Federal Circuit’s Allergan Decision Provides Some ODP Protection Practical Considerations for Contending with In re Cellect Potential Patent Applicant and Owner Strategies After In re Cellect On August 28, 2023, the Federal Circuit decided In re Cellect, which affirmed the US Patent and Trademark Office’s (USPTO’s) determination that patents awarded statutorily mandated PTA...
Electrification and specialist training associated with decreased neonatal mortality and increased admissions in Sierra Leone
BGH Bo Government Hospital CHO Community Health Officer SCBU Special Care Baby Unit There is a developing evidence base around infrastructural changes, such as electrification, and key indicators in neonatal units in low-income settings. From 2015 to 2019, the neonatal service at Bo Government Hospital, Sierra Leone, evolved from delivery in a general paediatrics ward to a dedicated special care baby unit with trained staff and a reliable electricity supply.
FGL - FINBOND GROUP LIMITED - Acquisition of additional shareholding in Americash Holding LLC and CreditBox.com LLC - 16/09/2024
Acquisition of additional shareholding in Americash Holding LLC and CreditBox.com LLC Finbond Group Limited (Registration number: 2001/015761/06) Share code: FGL ISIN: ZAE000138095 ("Finbond" or "the Company" or "the Group") ACQUISITION OF ADDITIONAL SHAREHOLDING IN AMERICASH HOLDING LLC AND CREDITBOX.COM LLC 1.
$100,000 Secured for Water Main Replacement Project in Port Dickinson
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Investors following the 'momo' may be missing out on a growing opportunity
As published in the Financial Post on August 25, 2024. British pop band Dead or Alive had a massive hit in the mid-80s with their song “You Spin Me Round (Like a Record)” on their “Youthquake” album. It’s a catchy little number. Over on the other side of the pond, in the investment world, something else is catching on—renewed investor interest in small cap stocks. They, too, have been spinning round, right round, in a long-awaited comeback in sentiment and capital inflows.
Investors following the 'momo' may be missing out on a growing opportunity Original
Rate cuts in Canada and possibly in the U.S. are pushing smaller companies — often viewed as cyclical and riskier — out of a multi-year slumber Published Aug 25, 2024 • Last updated 5 minutes ago • 3 minute read You can save this article by registering for free here. Or sign-in if you have an account. Traders work on the floor of the New York Stock Exchange during morning trading on Aug. 23 in New York City. Photo by Michael M.
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