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David Dowling

Iowa
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Articles

Incorporating meningeal immunity into vaccine development - Nature Communications

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By David Dowling, Manisha Menon
| Nature Verified
Abstract Meningeal immunity, a less-studied aspect of neuroimmune interactions, has recently come under the spotlight owing to the characterization of meningeal lymphatic vessels draining of the central nervous system (CNS). This changing landscape has begun to impact how vaccinologists and immunologists approach early pre-clinical vaccine development, including decentering the antigen, with a greater focus on the role of formulation science and route of delivery.
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What Are the Key Takeaways From Rachel Reeves’ Spending Review and Who Will be the Biggest Winners? | JD Supra

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By David Dowling
| JD Supra
Rachel Reeves, the UK’s Chancellor of the Exchequer, has revealed the Government’s Spending Review 2025 (SR25) setting out departmental budgets until 2029 and capital investment until 2030. The SR25 is in line with the Government’s ambitions to fix the foundations of the UK economy, kick-start and support economic growth, improve the healthcare system, increase defence spending, and secure domestic energy supply (amongst others).
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Deep Phenomics of Pattern Recognition Receptor Agonist Specific Activation of Human Blood

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By Soumik Barman, Arsh Patel, Aisling Kelly, David Dowling
| BioRxiv
Abstract Human whole blood (WB) immunophenotyping may represent the in vivo immunological state with better fidelity than artificially isolated peripheral blood mononuclear cells (PBMCs). We used a deep phenomics modeling approach to elucidate the quantitative differences in major immune cell lineages in WB and PBMC compartments in a steady-state in vitro setting. We studied functional innate immune responses induced by pattern recognition receptor agonist adjuvants (PRRa).
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