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David Glahn

As seen in: Nature, JAMA Psychiatry, BioRxiv
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Articles by David Glahn

Determinants of functional burden pleiotropy and gene dosage responses across human traits

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By Sayeh Kazem, Jane Yang Verified, Florian Benitiere, Guillaume Huguet, Josephine Mollon, Thomas Renné, Laura Schultz, Emma Knowles, Worrawat Engchuan, Bhooma Thiruvahindrapuram, Jeffrey MacDonald, Celia M. T. Greenwood, Stephen Scherer, Laura Almasy, Jonathan Sebat, David Glahn, Guillaume Dumas, Sébastien Jacquemont, Omar Shanta
| Nature Verified
Abstract Pleiotropic and monotonic effects of gene dosage are central to understanding comorbidities in developmental pediatric and psychiatric disorders, yet the underlying biological processes are not well characterized. Here we develop a functional burden analysis to investigate the association of all protein-coding copy-number variants, genome-wide, with 43 complex traits in approximately 500,000 UK Biobank participants.
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Brain Morphology Mediators of the Association of Childhood Trauma With Bipolar Disorder : An International ENIGMA Bipolar Disorder Working Group Study

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By Leonardo Tozzi, Maria R. Dauvermann, Emma Corley, Andréa Fernandes, Melody J. Y. Kang, Yanghee Im, Leila Nabulsi, Roberto Goya-Maldonado, Klaus Berger, Marco Hermesdorf, Hilary P. Blumberg, Lejla Colic, Tamsyn Van Rheenen, Elysha Ringin, Susan L Rossell, James A. Karantonis, Lisa Furlong, Tilo Kircher, Frederike Stein, Udo Dannlowski, Dominik Grotegerd, Jair C. Soares, Mon-Ju Wu, Giovana Zunta-Soares, Benson Mwangi, Joaquim Radua, Enric Vilajosana, Eduard Vieta, Melissa Green, Emilie Olié, Guillaume Clain, Francesco Benedetti, Elisa MT Melloni, Beatrice Bravi, Delfina Janiri, Daniela Vecchio, Fabrizio Piras, Nerisa Banaj, Gabriele Sani, Gloria Roberts, Janice M. Fullerton, Bronwyn Overs, Philip Mitchell, Jonathan Savitz, Lakshmi N Yatham, Josselin Houenou, Marion Leboyer, Amanda L. Rodrigue, Amanda Bautista Rodrígue, David Glahn, Sophia I. Thomopoulos, Neda Jahanshad, Paul Thompson, Ole A. Andreassen, Christopher R. K. Ching, Dara M. Cannon, Yann Quidé
| JAMA Psychiatry Verified
Brain Morphology Mediators of the Association of Childhood Trauma With Bipolar Disorder: An International ENIGMA Bipolar Disorder Working Group Study Key Points Question Is the association of childhood trauma and bipolar disorder mediated by brain structure?
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Psychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis - Molecular Psychiatry

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By Joaquim Radua, Brian Hallahan, Christoph Abe, Dag Alnæs, Silvia Amoretti, Jochen Bauer, Francesco Benedetti, Michael Berk, Erlend Bøen, Joscha Böhnlein, Beatrice Bravi, Udo Dannlowski, Caroline Demro, Torbjørn Elvsåshagen, Maria Forte, Janice M. Fullerton, David Glahn, Benjamin I. Goldstein, Ian H. Gotlib, Roberto Goya-Maldonado, Melissa Green, Dominik Grotegerd, Tim Hahn Verified, Tomas Hajek, Josselin Houenou, Fleur M Howells, Kody G. Kennedy, Tilo Kircher, Anna Luisa Klahn, Maximilian Konowski, Rayus Kuplicki, Mikael Landén, Bradley J. MacIntosh, Hannah Meinert, Susanne Meinert, Philip Mitchell, Igor Nenadic, Bronwyn Overs, Nadine Staples Parker, Godfrey Pearlson, James J. Prisciandaro, Yann Quidé, Amanda L. Rodrigue, Amanda Bautista Rodrígue, Fabio Sambataro, Jonathan Savitz, Freda Scheffler, Kang Hee Sim, Jair C. Soares, Aleix Solanes, Scott R. Sponheim, Dan Stein, Frederike Stein, Sophia I. Thomopoulos, Eduard Vieta, Lars T. Westlye, Daniel Wolf, Mon-Ju Wu, Dara M. Cannon, Ole A. Andreassen, Colm McDonald, Sinead King, Márcio Gerhardt Soeiro-de-Souza
| Nature Verified
Abstract MRI studies in bipolar disorder (BD) have yielded inconsistent findings, partly due to the varied use of psychotropic medications. This study utilised a mega-analysis approach, accounting for concurrent medication status (syndrome-based and Neuroscience-based Nomenclature (NbN) classifications), in order to assess the association of medication status with subcortical brain volumes in BD.
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Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium | Molecular Psychiatry

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By Seyed M. Kia, Wiepke Cahn, Nerisa Banaj, Katharina Brosch, Rachel M. Brouwer, Vince Calhoun, Sunah Choi, Young-Chul Chung, Derin Cobia, Sirio Cocozza, Andrea de Bartolomeis, Marta Di Forti, Alexandre Dumais, Ulrika Evermann, Kira Flinkenflügel, Foivos Georgiadis, David Glahn, Janik Goltermann, Melissa Green, Dominik Grotegerd, Hilleke Hulshoff Pol, Felice Iasevoli, Andriana Karuk, Minah Kim, Tilo Kircher, Matthias Kirschner, Jun Soo Kwon, Rebekka Lencer, Tiago R Marques, Susanne Meinert, Robin Murray, Igor Nenadic, Godfrey Pearlson, Fabrizio Piras, Giuseppe Pontillo, Yann Quidé, Amanda L. Rodrigue, Amanda Bautista Rodrígue, Kang Hee Sim, Antonin Skoch, Gianfranco Spalletta, Filip Spaniel, Florian Thomas-Odenthal, David Tomecek, Mario Tranfa, Jessica Turner, Daniela Vecchio, Adrian Wroblewski, Arturo Brunetti
| Nature Verified
Abstract It is hypothesised that structural brain abnormalities in individuals with schizophrenia are associated with aggressive behaviour, but this has not been tested directly. We pooled magnetic resonance imaging and clinical data from 2095 patients and 2861 healthy control subjects across 20 sites of the ENIGMA-Schizophrenia Working Group.
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Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

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By Foivos Georgiadis, Sara Larivière, David Glahn, Elliot Hong
| BioRxiv
New Results Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study Foivos Georgiadis, Sara Lariviere, David Glahn, Elliot Hong, Peter Kochunov, Bryan Mowry, Carmel Loughland, Christos Pantelis, Frans Henskens, Melissa Green, Murray Cairns, Patricia Michie, Paul Rasser, Paul Tooney, Rodney Scott, Stanley Catts, Ulrich Schall, Vaughan Carr, Yann Quide, Axel Krug, Frederike Stein, Igor Nenadic, Katharina Brosch, Tilo Kircher, Raquel Gur, Ruben...
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Connectome architecture shapes large-scale cortical reorganization in schizophrenia: a worldwide ENIGMA study

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By Sara Larivière, David Glahn, Foivos Georgiadis, Elliot Hong
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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Convergence and Divergence of Rare Genetic Disorders on Brain Phenotypes

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By Armin Raznahan, David Glahn
| jamanetwork.com
Convergence and Divergence of Rare Genetic Disorders on Brain Phenotypes: A Review | Genetics and Genomics | JAMA Psychiatry | JAMA Network [Skip to Navigation] JAMA Psychiatry. 2022;79(8):818-828. doi:10.1001/jamapsychiatry.2022.1450 Importance Rare genetic disorders modulating gene expression—as exemplified by gene dosage disorders (GDDs)—represent a collectively common set of high-risk factors for neuropsychiatric illness.
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Fast and powerful genome wide association of dense genetic data with high dimensional imaging phenotypes

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By Habib Ganjgahi, Anderson M. Winkler, David Glahn, John Blangero
| Nature Verified
Several approximate or exact methods have been proposed to speed up LMM-based testing. Approximate methods assume the total polygenic random effect is same for all markers under the null hypothesis of no marker effect, hence the relevant residual genetic variance component is estimated only once using all markers. In contrast, exact methods, which is the recommended LMM practice19,20,25,35,46, estimate a residual variance component conditional on each marker’s effect.
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Fast and Powerful Genome Wide Association Analysis of Dense Genetic Data with High Dimensional Imaging Phenotypes

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By Anderson M. Winkler, David Glahn, Habib Ganjgahi, John Blangero
| BioRxiv
Fast and Powerful Genome Wide Association Analysis of Dense Genetic Data with High Dimensional Imaging Phenotypes Habib Ganjgahi, Anderson M. Winkler, David C. Glahn, John Blangero, Brian Donohue, Peter Kochunov, Thomas E. Nichols bioRxiv 179150; doi: https://doi.org/10.1101/179150
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Psychotic Experiences and Neuropsychological Functioning in a Population-based Sample

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By Anthony David, Craig Morgan, Josephine Mollon, Souci Frissa, David Glahn
| JAMA Psychiatry Verified
Importance  Psychotic experiences in early life are associated with neuropsychological impairment and the risk for later psychiatric disorders. Psychotic experiences are also prevalent in adults, but neuropsychological investigations spanning adulthood are limited, and confounding factors have not been examined rigorously.
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