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Laura Schultz on Muck Rack

Laura Schultz

Pitman
As seen in: Nature, The Conversation, U.S. News and World Report, Yahoo, BioRxiv, Cell Press, Roanoke Times, Bryan-College Station Eagle, Yakima Herald-Republic, Grand Island Independent and
Flutist/piccolist, statistics professor, ex-neuroscientist, school board member, mother.
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Articles

Determinants of functional burden pleiotropy and gene dosage responses across human traits

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By Sayeh Kazem, Jane Yang Verified, Florian Benitiere, Guillaume Huguet, Josephine Mollon, Thomas Renné, Laura Schultz, Emma Knowles, Worrawat Engchuan, Bhooma Thiruvahindrapuram, Jeffrey MacDonald, Celia M. T. Greenwood, Stephen Scherer, Laura Almasy, Jonathan Sebat, David Glahn, Guillaume Dumas, Sébastien Jacquemont, Omar Shanta
| Nature Verified
Abstract Pleiotropic and monotonic effects of gene dosage are central to understanding comorbidities in developmental pediatric and psychiatric disorders, yet the underlying biological processes are not well characterized. Here we develop a functional burden analysis to investigate the association of all protein-coding copy-number variants, genome-wide, with 43 complex traits in approximately 500,000 UK Biobank participants.
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The overlapping genetic architecture of psychiatric disorders and cortical brain structure - Nature Mental Health

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By Zhiqiang Sha, Varun Warrier, Laura Schultz, Alison K. Merikangas, Ruben C. Gur, Michael J. Gandal, Jakob Seidlitz, Ole A. Andreassen
| Nature Verified
Abstract Both psychiatric vulnerability and cortical structure are shaped by the cumulative effect of common genetic variants across the genome. However, the shared genetic underpinnings between psychiatric disorders and brain structural phenotypes, such as thickness and surface area of the cerebral cortex, remain elusive.
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Exposomic and polygenic contributions to allostatic load in early adolescence - Nature Mental Health Original

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By Kate Tran, Tyler Moore, Barbara H. Chaiyachati, Laura Schultz, Nikolaos P. Daskalakis
| Nature Verified
Abstract Allostatic load (AL) is the cumulative ‘wear and tear’ on the body due to chronic adversity. We tested the poly-environmental (exposomic) and polygenic contributions to AL and their combined contribution to adolescent mental health. In this cohort study of N = 5,036 diverse youth (mean age 12 years) from the Adolescent Brain Cognitive Development Study, we calculated a latent AL score, childhood exposomic risk and genetic risk.
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