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David Haslam

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Articles

The gut virome in children undergoing hematopoietic cell transplantation is diverse and a site for viral reactivation

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By Pooja Khandelwal, David Haslam, Azada Ibrahimova, Benjamin L. Laskin, Aaron Webster, Jason T. Blackard, Kelly Lake, Nathan Luebbering, Sheyar Abdullah, Stella Davies, Colin Hoerth
| Nature Verified
The role of the gut virome in children undergoing allogeneic hematopoietic cell transplantation (HCT) is unknown. A single prior study of the adult HCT virome showed predominance of Anelloviruses and Picobirnaviruses, the latter predicting acute graft versus host disease (GVHD) [1], but these data cannot be extrapolated to children due to known age-related virome differences [2].
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Tu1900 PEDIATRIC ACUTE PANCREATITIS ASSOCIATED GUT DYSBIOSIS IS ASSOCIATED WITH POOR QUALITY OF LIFE SCORES

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By James W. Varni, Lee A Denson, Alexander Nasr, Chinenye R. Dike, Ruoxi Yang, Shanlin Ke, David Haslam, Georgios I Papachristou, Maisam Abu-El-Haija
| Gastrointestinal Endoscopy Verified
Also available on ScienceDirect
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Natural maternal immunity protects neonates from Escherichia coli sepsis

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By Raymond E. Diep, Ujjwal Adhikari, Kübra Gökçe Tezel, Giang Pham, Giang Phạm, Allison R. Burrell, Mary A. Staat, Minh-Duy Phan, Kate Peters, Mark Schembri, Scott Saunders, David Haslam, John Erickson, Susana Chavez-Bueno
| Nature Verified
Abstract Escherichia coli is a leading cause of neonatal sepsis, with infection occurring in approximately one in every 1,000 live births1,2. However, with E. coli colonization beginning soon after birth3,4,5 and defects in neonatal host defence maturation6,7,8,9, an alternative consideration is why infection does not occur even more frequently. Here we show that newborn babies with E. coli sepsis have selectively reduced vertically transferred natural antibodies that recognize E.
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