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David Long

As seen in: Santa Monica Daily Press, Nature, Wiley Online Library, Bandcamp Daily, Cambridge University Press & Assessment, Frontiers, Manawatū Standard, MDPI, Stuff.co.nz, Sunday News (New Zealand), Sunday Star-Times and
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Articles

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

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By Apoorva Uboveja, Raquel Buj, Amandine Amalric, Hui Wang, Naveen Kumar Tangudu, Aidan Cole, Richard Fang, Miho Naruse, Zhentai Huang, Emily Megill, Daniel S. Kantner, Adam Chatoff, Hafsah Ahmad, Mariola M. Marcinkiewicz, Sarah Graff, Ellen De Pieri, Frank P. Vendetti, Jeff Danielson, Erika Dahl, Jennifer Pennise, Alison Jaccard, Kristine Cooper, Francesmary Modugno, Nadine Hempel, Wayne Stallaert, Christopher J. Bakkenist, Simone Sidoli, Kathryn Wellen, Benjamin G. Bitler, David Long, Nathaniel W Snyder, Katherine M. Aird, Baixue Yang, Julie A. Disharoon, Evan Levasseur, Andrea Andress Huacachino, Esther Elishaev, Lauren Borho
| Nature Verified
Abstract Homologous recombination (HR) deficiency increases sensitivity to DNA-damaging agents that are commonly used to treat cancer1. In HR-proficient cancers, the metabolic mechanisms that drive response or resistance to DNA-damaging agents remain unclear. Here we have identified that depletion of α-ketoglutarate (αKG) sensitizes HR-proficient cells to DNA-damaging agents by metabolic regulation of histone acetylation.
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Distinct repair outcomes from single and convergent replication fork collapse

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By Sara C Conwell, Khushi Patel, Savannah J. Weeks-Pollenz, Steven N Dahmen, Matthew T Cranford, William G. Dunphy, David Long, David Cortez, James Dewar
| Nature Verified
Abstract Replication fork collapse at single-strand DNA breaks threatens genome stability but how such forks are repaired and resolved has remained unclear. Here we replicate site-specific nicks with single or converging replication forks in Xenopus laevis egg extracts. Collapse of a single fork generates a single-ended double-strand break (DSB) that undergoes homologous recombination to yield stable D-loops and end-to-end fusions, yet does not restart DNA synthesis.
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Why you should pay attention to the weather in space

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By David Long
| RTE Brainstorm
Updated / Tuesday, 3 Feb 2026 12:20 NASA Solar Dynamics Observatory image of a solar flare. Photo: NASA/SDO Analysis: Solar flares and geomagnetic storms can have very significant effects on satellites, airplanes and GPS and electrical systems Weather in Ireland is a daily topic of conversation, with the constant potential for rain, sun, heat, and snow - sometimes all in the same day. This concept of changeable weather is something that must also be considered in space.
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