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Articles by David Merrell
Publisher Correction: Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma
Correction to: Nature Cancer https://doi.org/10.1038/s43018-026-01179-2, published online 3 June 2026. In the version of the article initially published, in the Abstract, “we profiled 181 ICB-treated GBM samples with bulk DNA sequencing” should have read “we profiled 181 ICB-treated GBM cases using bulk DNA sequencing”.
Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma
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Abstract The determinants of immune checkpoint blockade (ICB) response in glioblastoma (GBM) with wild-type isocitrate dehydrogenase remain poorly understood. Here we profiled 181 ICB-treated GBM samples with bulk DNA sequencing, bulk RNA sequencing and single-nucleus RNA sequencing to investigate the genomic features associated with ICB outcomes.
By Jack Ghannam, Julian Bryan, Jakob Weiss, Daniel Kovarsky, David Merrell, Conor Messer, Kristy Schlueter-Kuck, Geoffrey G Fell, Mary Jane Lim-Fat, Gilbert Youssef, Rifaquat Rahman, Lei Qin, Kathleen L. Pfaff, Andrew Gans Verified, Emma Lin, Raymond Y. Huang, Brian P. Danysh, Laxmi Parida, Shuqiang Li, Patrick Y Wen, E. Antonio Chiocca, Donna S. Neuberg, Keith L. Ligon, Itay Tirosh, David A Reardon, Gad Getz, Catherine J. Wu, J. Thomas Janes III, McKayla Van Orden
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Nature
Verified
Faith | ‘He is risen’ holds deeper meaning after heart surgery
I waited in the hospital on a Saturday in anticipation of an operation on my heart the next day. The surgery would replace a major artery that was “diseased and calcified” along its length, as well as two other arteries that were less dangerous. I had not been concerned the day before. It was only a mild heart attack due to blockage of a small artery that brought me to the emergency room. I had received a blessing on Friday by a leader in my church.
It's Time to Update Your Maxon App, Folks! -
Maxon sent out an email to subscribers of Maxon tools explaining that you must update your Maxon app to version 2024.5 or later by a certain date to maintain access to your licensing and installations. Don’t worry, if your Maxon App is at version 2024.5 or higher, you are good to go.
Syria, Yemen conflict zones face potential devastation from large coronavirus outbreak
Posted By: Radio Pacific, Inc May 1, 2020 @ 3:22 am ABC World News AlpamayoPhoto/iStockBy IAN PANNELL and DAVID R MERRELL, ABC News (NEW YORK) — Syria and Yemen face potential devastation if a large-scale outbreak of the novel coronavirus hits the war-torn regions, according to humanitarian aid organizations. “The COVID-19 pandemic threatens to be a global socio-economic earthquake.
Syria, Yemen conflict zones face potential devastation from large coronavirus outbreak
AlpamayoPhoto/iStockBy IAN PANNELL and DAVID R MERRELL, ABC News (NEW YORK) — Syria and Yemen face potential devastation if a large-scale outbreak of the novel coronavirus hits the war-torn regions, according to humanitarian aid organizations. “The COVID-19 pandemic threatens to be a global socio-economic earthquake.
KTBB.com - News Weather Talk
Posted/updated on: May 1, 2020 at 6:49 am AlpamayoPhoto/iStockBy IAN PANNELL and DAVID R MERRELL, ABC News (NEW YORK) — Syria and Yemen face potential devastation if a large-scale outbreak of the novel coronavirus hits the war-torn regions, according to humanitarian aid organizations. “The COVID-19 pandemic threatens to be a global socio-economic earthquake.
Syria, Yemen conflict zones face potential devastation from large coronavirus outbreak - World News - ABC News Radio
AlpamayoPhoto/iStockBy IAN PANNELL and DAVID R MERRELL, ABC News (NEW YORK) -- Syria and Yemen face potential devastation if a large-scale outbreak of the novel coronavirus hits the war-torn regions, according to humanitarian aid organizations. "The COVID-19 pandemic threatens to be a global socio-economic earthquake.
KTBB.com - News Weather Talk
Syria, Yemen conflict zones face potential devastation from large coronavirus outbreak Posted/updated on: May 1, 2020 at 6:22 am AlpamayoPhoto/iStockBy IAN PANNELL and DAVID R MERRELL, ABC News (NEW YORK) -- Syria and Yemen face potential devastation if a large-scale outbreak of the novel coronavirus hits the war-torn regions, according to humanitarian aid organizations. "The COVID-19 pandemic threatens to be a global socio-economic earthquake.
Syria, Yemen conflict zones face potential devastation from large-scale coronavirus outbreak
Syria and Yemen face potential devastation if a large-scale outbreak of the novel coronavirus hits the war-torn regions, according to humanitarian aid organizations. "The COVID-19 pandemic threatens to be a global socio-economic earthquake.
Syria, Yemen conflict zones face potential devastation from large coronavirus outbreak
By IAN PANNELL and DAVID R MERRELL, ABC News (NEW YORK) -- Syria and Yemen face potential devastation if a large-scale outbreak of the novel coronavirus hits the war-torn regions, according to humanitarian aid organizations. "The COVID-19 pandemic threatens to be a global socio-economic earthquake.
Syria, Yemen conflict zones face potential devastation from large coronavirus outbreak - KTBB News, Weather, Talk
Advertisement Syria, Yemen conflict zones face potential devastation from large coronavirus outbreak Posted/updated on: May 1, 2020 at 6:22 am AlpamayoPhoto/iStockBy IAN PANNELL and DAVID R MERRELL, ABC News (NEW YORK) -- Syria and Yemen face potential devastation if a large-scale outbreak of the novel coronavirus hits the war-torn regions, according to humanitarian aid organizations. "The COVID-19 pandemic threatens to be a global socio-economic earthquake.
WHMI 93.5 FM Radio Station — Livingston County Michigan
AlpamayoPhoto/iStockBy IAN PANNELL and DAVID R MERRELL, ABC News (NEW YORK) -- Syria and Yemen face potential devastation if a large-scale outbreak of the novel coronavirus hits the war-torn regions, according to humanitarian aid organizations. "The COVID-19 pandemic threatens to be a global socio-economic earthquake.
How an Epic Event Challenge Made Team AOO ‘Rebels with a Cause’
The AOO team had to react fast to a venue change--and came through for a successful event. David E. Merrell | Dec 18, 2019 It was Monday and elements were in motion for a Thursday evening event, the fourth annual Rebels with a Cause--a fundraiser for the Lawrence J. Ellison Institute of Transformative Medicine, to which 450 high-profile guests were expected. Visionaries in medicine, philanthropy, tech, entertainment and education had RSVP’d.
Monday's record-breaking Dow drop may have little impact, experts say
Monday marked the largest single-day drop in the history of the Dow Jones Industrial Average in terms of index points. Interested in Stock Market? Add Stock Market as an interest to stay up to date on the latest Stock Market news, video, and analysis from ABC News. But that doesn't mean it will necessarily have a lasting impact, experts told ABC News.
Marvel minds behind 'Secret Empire' tease returns of Hydra-Cap, Black Widow
Marvel's "Secret Empire" comic event ended with the Captain America fans know and love returning to smash his evil, cosmic-cube re-written counterpart with Thor's hammer, showing that Hydra-Cap's "worthiness" was all a facade. But the scars of Stevil's reign remain, and even Kobik could not or would not re-write reality to give this story a truly happy ending.
The Current: Environment L.A.
The USC Trojans head into the 2017 season with their highest preseason AP ranking since 2012. While their schedule is by no means easy, they have the opportunity to ease into the year with the first game.
Captain America's comeback: What this means for future of Marvel Comics
After more than a year fighting for Hydra, the Captain America comic book fans know and love is back. In "Secret Empire" issue 10, out this week, Captain America was forced to face his classic self, and in a showdown of good versus evil, good prevailed hands down.
Captain America's comeback: What this means for future of Marvel Comics
After more than a year fighting for Hydra, the Captain America comic book fans know and love is back. In "Secret Empire" issue 10, out this week, Captain America was forced to face his classic self, and in a showdown of good versus evil, good prevailed hands down.
Country music legend Charley Pride has 'no regrets' in decades-long career
Charley Pride received a Grammy lifetime achievement award for his record-breaking career in country music, but his first ambition was to break records on the baseball diamond. Growing up in Sledge, Mississippi, Pride saw the game of baseball as a way to get out of the cotton fields where his sharecropper father toiled.
'Star Wars': Everything you never knew about Darth Vader
Fans are two issues in on the new 2017 run of Marvel Comics' "Darth Vader," the books that fill in the backstory of everyone's favorite Jedi-turned-Sith Lord. These books are canon, so they count for the official story and lead right into the movies.
5 burning questions on today's political climate
ABC News chief political analyst Matthew Dowd answered viewers' questions on this week's episode of "Common Sense with Matt Dowd." 1. Katie, in Dalton, Pennsylvania asked: How do we get back to a respect for facts in government? Dowd responded, "We have to do it. We have to start that, we have to do that in our own lives." He emphasized personal responsibility, saying "do it yourself first, so tune into diverse sources of information, gather from many different sources of information.
Special Olympics athlete spends day playing basketball with NBA star
Brad Smith never imagined in his wildest dreams that he'd be in New York with his younger brother Noah and the Phoenix Suns' star guard Devin Booker. Noah, 11, was born with a hole in his heart, and would undergo multiple surgeries throughout his young life. Brad said doctors told the family hours after Noah was born that he might not "walk, talk" and wouldn't have a good quality of life. They even suggested putting him in a home.
5 things to know about Philadelphia's Natiive Sonz
Natiive Sonz have only been singing together for a couple months, but they share a bond forged by their hometown of Philadelphia and a passion for making music. Their new single "All The Time" is out now on streaming platforms, as is their second song, "Not Over Me." Here are five things you should know about the new group. 1. The group's lead singer, Titus Martel, started singing on trains and on the streets to make extra cash.
Ride a Model Train Through Miniature New York at the NY Botanical Garden's Holiday Train Show
The New York Botanical Garden is celebrating the 25th anniversary of its holiday train show in which model trains chug through exotic foliage alongside more than 150 miniature replicas of famous New York landmarks. Each miniature landmark is handmade with only organic plant materials like twigs, pine cones, leaves and even resin, which is used to create the appearance of glass windows. The exhibit has grown substantially throug the years but many of the models have been around a long time.
5 Things We Learned at 'Gilmore Girls' Fan Fest
Fans of the cult classic series "Gilmore Girls" are flocking to a small town in Connecticut for a weekend of activities, which kicked off Friday, in anticipation of the series' revival next month. "Gilmore Girls" stars Lauren Graham and Alexis Bledel, who portrayed Lorelai and Rory Gilmore respectively. The series, set in the fictional Connecticut town of Stars Hollow, centered on their close relationship. We caught up with fans, cast and crew for a peek into the "Gilmore" world.
Willy Wonka Candy Factory Spill Sickens Employees
The Itasca Fire Protection District responded to an early-morning call at the Willy Wonka Candy Factory in the Chicago suburb to find the building being evacuated. Employees complained of respiratory problems after about 5 gallons of a humidity-regulating solution of lithium chloride leaked from the ventilation system, according to Deputy Chief John Radzinski.
Fireworks Set Off in Phoenix Walmart, Some Mistake It for Gunfire
Customers at a Phoenix Walmart feared the worst this week when a fireworks display erupted in an aisle, prompting some customers to think a gunman had opened fire in the store, officials said. "A lot of people thought they were being shot at," said Ardell Deliz of the Phoenix Fire Department. Fortunately, no one was injured in the Wednesday incident. "We treated everyone for smoke inhalation on the scene," Deliz told ABC News, but no one was transferred to a hospital.
Farmers Create Fantastic Colorful Images in Rice Fields
Rice fields in Shenyang, in northeast China's Liaoning Province, have been transformed into works of art. It may look like paint, but the images are actually created by strategically growing different varieties of rice, and is a blessing tradition of the Xibe people, according to China Daily. The images achieve a 3-D effect thanks to technology that limits the plants' height, according to Imagine China. Farmers in Shenyang have been creating the images for an annual festival since 2012.
6-Year-Old Girl in Stable Condition After Shark Attack
A 6-year-old girl is in stable condition after being bitten by a shark Tuesday near Pirates Beach in Galveston, Texas. Marin Alice Melton of Kerrville, Texas, "is stable and maintains a gracious, positive attitude," said her father, Matthew Grove Melton, in a Facebook post. "She will be having multiple surgeries," he said, adding that "her vital signs are good." Marin suffered "significant soft tissue damage to a leg," according to the Galveston County Health District EMS.
Pull-Ups Record Broken for the Third Time in Five Weeks
Australian Caine Eckstein, 30, has usurped the throne of John Orth, who reigned as king of pull-ups for only a few days. Eckstein's record of 7,620 beat Orth's 7,600 pull-ups in 24 hours, a feat Orth is likely still recovering from as he accomplished it Saturday. Orth, in turn, beat Virginia high-schooler Andrew Shapiro's record of 7,306 set May 14. "At first he was really upset, he just wanted it to last a little longer," Andrew's mother, Stephanie Shapiro, told ABC News.
Abandoned by Smugglers, 34 Migrants Die of Apparent Thirst in Sahara Desert
A group of migrants traveling from Niger into Algeria were found dead last week, abandoned by human traffickers who were leading them, the Niger Ministry of Interior said in a statement. The migrants are presumed to have died from extreme thirst, as is common in the scorching temperatures of the landlocked desert environment. Of the 34 migrants who died, only two have been identified, according to the statement, as citizens of Niger.
As Kansas Defies Transgender Directive, School Funding and Civil Rights in Question
After the Kansas Board of Education and state legislature announced yesterday that the state will continue to apply its own gender policies on school bathroom use, instead of following the Obama administration's directive to allow students to use bathrooms associated with their chosen gender identity, questions remain about school funding and student rights, advocates say. The Kansas Board of Education said it made the unanimous decision to preserve local authorities' flexibility.
Orlando Girl Makes Cards for Victims' Families in Hopes They Feel 'Much, Much Better'
Madison Lindsey, 6, was upset that her mother, Lynsey Pink, had to work late this weekend, but when she learned why, she pitched in herself in the best way she knew how. Pink, a nursing student at Valencia College in Orlando, has been dealing with the overflow of patients since the Pulse nightclub shooting on Sunday, she told ABC News. When her daughter asked where she'd been, Pink replied, "I was out helping people." Madison wanted to help, too, but didn't know how.
Brits Begin Search for Another Lost King's Remains in Parking Lot
Historians are starting the search for another lost king thought to be buried under a parking lot. King Henry I of England, who took the throne in year 1100, died without an heir in 1135 of an illness thought to be brought on by eating lampreys, a type of jawless fish, against his doctor's orders. His body was interred at Reading Abbey, according to historian C. Warren Hollister's book Henry I.
FDA Warns Whole Foods for 'Serious Violations' at Food Manufacturing Facility
A Whole Foods manufacturing facility in Massachusetts has violated several of the Food and Drug Administration's regulations for "manufacturing, packing, or holding human food," according to a June 8 letter sent to Whole Foods Markets' Co-Chief Executive Officers, John Mackey and Walter Robb.
Ancient Hidden Cities in Cambodia Uncovered by Laser-Equipped Helicopters
Researchers using helicopter-mounted lasers have discovered a complex system of lost cities from the Khmer civilization in Cambodia, marking a pivotal point in the field of archaeology. The Cambodian Archaeological Lidar Initiative (CALI) published findings today that may change the way historians view lost cultures.
Openly Gay Imam Reacts to Sunday's Shooting in Orlando
Members of the LGBT community descended upon New York City's Stonewall Inn last night to gather together after a terrorist killed 49 people in an Orlando nightclub. Many in attendance didn't know exactly why they came, but they knew the community would be there. Others knew exactly why they came. "I was hoping to hear a clear condemnation of Islamophobia," said Brian Kates, a film editor standing by the NYPD-erected railing. "We should show solidarity with everyone.
'Noah's Ark' Survives Collision With Norwegian Coast Guard Vessel
A floating museum based on the biblical story of Noah and the flood was damaged in a collision with a moored Norwegian Coast Guard patrol vessel in the Oslo harbor. No injuries were reported in the accident that left both vessels damaged, Coast Guard officials told The Associated Press, and there were apparently no animals aboard.
Texas High School Valedictorians Come Out as Undocumented Immigrants, Face Backlash
Larissa Martinez warned the audience at McKinney Boyd High School's graduation ceremony this week that she was not going to give a typical valedictory speech. "I am one of the 11 million undocumented immigrants living in the shadows of the United States," she said at the ceremony, a video of which was captured by the school district in McKinney, Texas. In fact, two Texas high school valedictorians have announced they are undocumented immigrants.
Petition for New Metal Element to be Named After Lemmy Kilmister
The newest heavy metal quartet has debuted, but to the disappointment of more than 150,000 Motörhead fans, none of the members will be named for late rock legend Lemmy Kilmister, who died last December. The International Union of Pure and Applied Chemistry (IUPAC) announced Wednesday that four newly discovered elements added to the periodic table have been named by their discoverers and are up for public review.
81-Year-Old Pilot Makes Emergency Landing on Glacier, All Passengers Survive
An 81-year-old pilot had to make a quick decision when his plane stalled in the mountains of British Columbia on June 5. Vern Hannah and his passengers, Zbigniew Jedynakiewicz, who goes by Peter, and Alan Widelski, survived a day and a half in the Canadian wilderness after making an emergency landing on a glacier. They were rescued when a snowmobiler spied their downed airplane, according to Jeff Olssen of the Canadian Coast Guard.
200 Show to Funeral of Veteran With No Known Relatives After Internet Campaign
Four people were expected to attend the funeral of Serina Vine, a formerly homeless veteran of World War II. Instead, about 200 showed up to honor her after veterans' groups organized a social media campaign, since she had no known living relatives. Vine, a graduate of the University of California, served in the Navy from 1944 to 1946 in radio intelligence and spoke three languages, according to the obituary published by A. L. Bennett and Son Funeral Home. Vine's story hit home for Army Maj.
200 Show to Funeral of Veteran With No Known Relatives After Internet Campaign
Four people were expected to attend the funeral of Serina Vine, a formerly homeless veteran of World War II. Instead, about 200 showed up to honor her after veterans' groups organized a social media campaign, since she had no known living relatives. Vine, a graduate of the University of California, served in the Navy from 1944 to 1946 in radio intelligence and spoke three languages, according to the obituary published by A. L. Bennett and Son Funeral Home. Vine's story hit home for Army Maj.
The 2 Big Challenges: How to Run a Business Yet Stay Creative
Being the creative director and executive-level designer, combined with the fact that I am the owner of the company, keeps me on my toes at all times. I am in a constantly juggling all the decisions and responsibilities an owner gets involved in administratively, such as our marketing and sales strategy, but then in an instant I may have to turn around and think creatively in order to knock client off their seats with an intangible concept.
LAUSD Closes All Schools Because Of Email Threat
The LAUSD will reopen its schools tomorrow after today's district-wide closure in response to an emailed threat. Late last night, L.A. Police Chief Charlie Beck said school district administrators received an email threatening violence against all LAUSD schools. He said the email mentioned backpacks, explosive devices and assault rifles. Police say the email threat was routed through Germany, but they believe the email originated closer to home.
E-Cigarettes Under Fire For Causing Fires
Three people are suing the makers and sellers of popular e-cigarettes. In separate lawsuits filed today, the plaintiffs all claim to have suffered severe burns due to their devices exploding. Listen to the audio story here. Attorney Gregory L. Bentley, of Schernoff, Bidart, Echeverria and Bentley, represents the three plaintiffs, Vicente Garza, Daniel Califf and Gregory Phillips, Jr. While their suits are separate, each has a similar claim.
forecast special event design trends
How are trends decided upon? What higher power deems A or B to be what’s trending now? Truthfully, the answer lies in whose voice is the greatest. Trends are opinionated--and the greatest opinion--the loudest voice--shapes and molds the trend of the time. However, with this said, we as event professionals should be very cognizant of those trends. Aware of what the people are craving to see from our designs, proposals and end products.
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