David Perlmutter on Muck Rack

David Perlmutter

Naples
As seen in: The Empowering Neurologist Podcast, Apple Podcasts, IMDb, Medium, Yahoo Life, HuffPost, Nature, Harm Reduction Journal, Patreon, Substack, The Daily Beast and
Neurology, Functional Medicine, Nutrition, Author, Lecturer
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Articles

The polymerized protein response (PPR) is activated by genetic variants that polymerize in the ER and is mediated by NFκBp50

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By Admire Munanairi, David Rudnick, Jiansheng Huang, David Perlmutter
| Nature
Abstract In previous studies we have shown that accumulation of the polymerogenic variant ATZ that causes α1-antitrypsin deficiency (ATD) activates NFκB DNA binding. Here we discovered that this response, which we are naming the polymerized protein response (PPR), is characterized by NFκB p50 homodimers, distinct from the p50/p65 heterodimers in the canonical NFκB inflammatory response and the unfolded protein response (UPR).
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A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia

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By Farzaneh S Mirfakhar, Jacob Marsh, Chihiro Sato, Kylie J. Schache, Miguel A. Minaya, Roland E. Dolle, Stephen C. Pak, Gary Silverman, David Perlmutter, Shannon Macauley, Celeste M. Karch
| Nature
Abstract Tau accumulates in a group of neurodegenerative diseases known as tauopathies. A prevailing hypothesis has been that Tau degradation is impaired due to an age-related imbalance in the autophagy-lysosome pathway, but whether these defects are a cause or consequence of Tau accumulation remains unclear. Here we show that a disease-causing mutation in the MAPT gene, which encodes Tau, p.R406W, is sufficient to disrupt multiple steps of the autophagy-lysosome pathway in human neurons.
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David Perlmutter

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By David Perlmutter
| cbdb.cz
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