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David Shin

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Articles

A unified catalytic mechanism in bifunctional DNA glycosylases with an evolutionarily conserved aspartate-lysine dyad

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By Aleem Syed, Leonardo F. Serafim, Andrew S. Arvai, Irina G. Minko, Henry Tang, Altaf H. Sarker, Sudip S. Parikh, Chi-Lin Tsai, Albino Bacolla, David Shin, Richard Cunningham Verified, Shigenori Iwai, Dipanjan Chowdhury, R. Stephen Lloyd, Ivaylo Ivanov, John A. Tainer, Joy L. Huffman, Clifford D. Mol, Kenichi Hitomi
| Nature Verified
Abstract Bifunctional glycosylases, OGG1 for purines and NTH1 for pyrimidines, repair oxidized DNA bases via consecutive glycosylase and AP-lyase reactions, yet their catalytic relationships and lyase activity’s biological relevance remain unresolved. Here, we solved crystal structures of archaeal and human Ogg1 and Nth1 captured in key damage-recognition and catalysis-ready states, complemented by ab initio molecular dynamics simulations of their complete reaction trajectories.
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Enabling High-Performance AI PC Web Cameras Using eUSB2V2 Version of USB

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By David Shin
| All About Circuits Verified
As AI moves from the cloud to endpoint devices, SoC and system designs that enable intelligence to operate locally and in real time will become the new norm. By processing data closer to where it is captured, edge AI offers several advantages, such as lower latency, greater privacy, and reduced system power, all of which are key factors for modern electronics. AI PCs are taking on more sophisticated tasks such as presence detection and facial recognition.
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Trends in Racial and Ethnic Representation Among Vascular Surgery Residents Relative to Other Specialties Over the Past Decade

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By David Shin, Benjamin T. Viggiano
| Annals of Vascular Surgery Verified
Get full text access Log in, subscribe or purchase for full access. References 1. Rosamond, W.D. ∙ Chambless, L.E. ∙ Heiss, G. ... Twenty-Two–Year Trends in Incidence of Myocardial Infarction, Coronary Heart Disease Mortality, and Case Fatality in 4 US Communities, 1987–2008 Circulation. 2012 Apr 17; 125(15):1848-1857 2. Mozaffarian, D. ∙ Benjamin, E.J. ∙ Go, A.S. ... Executive Summary: Heart Disease and Stroke Statistics—2016 Update Circulation. 2016 Jan 26; 133(4):447-454 3.
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