Fabry Disease We appreciate the commentary by Lenders and Brand1 that addressed the determination of immunogenicity of pegunigalsidase alfa in our recent publication in the journal.2 Determination of the immunogenicity of pegunigalsidase alfa is important, and the possible interference of residual drug with antidrug antibody (ADA) detection has been previously addressed3 4 and also acknowledged in our manuscript.2 It should be noted that the primary outcomes analysis of the BALANCE study...