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Articles by David Wright
Single-nucleus profiling of social behaviour in a mutualistic reef fish
Abstract Complex social decision-making in vertebrates relies on a conserved network within the forebrain. However, the precise neural cell populations and gene regulatory networks that orchestrate these sophisticated social behaviours remain largely unresolved. Here, we present the first single-nucleus transcriptome atlas of the telencephalon in the cleaner wrasse Labroides dimidiatus, a remarkable model for advanced social cognition.
The psychiatric risk gene CACNA1C encodes distinct full-length isoforms in human brain, heart and aorta
Abstract CACNA1C is a risk gene for multiple psychiatric disorders and the CaV1.2 protein it encodes is a potential target for their treatment. It is known that alternative start exon usage and splicing of CACNA1C RNA results in multiple transcript isoforms. However, the identity of full-length isoforms, and their relative abundance between tissues, remains unknown.
26% of Working Americans Have Less Than One Month of Savings, Study Finds
Quikaid research finds 72% of workers who lost income due to injury or illness say the financial impact was worse than expected. More than three-quarters have worked through pain, illness, or burnout because they felt they could not afford to stop. SAINT PETERSBURG, FL, UNITED STATES, July 28, 2026 /EINPresswire.com/ -- For millions of American workers, a missed paycheck can quickly become a financial emergency.
Hyperreflective foci and subretinal drusenoid deposits as predictors of exudation in intermediate AMD eyes with contralateral neovascular AMD
Abstract To examine the prognostic significance of intraretinal hyperreflective foci (HRF) and subretinal drusenoid deposits (SDD) as predictors of atrophy presence and progression to exudative macular neovascularisation (eMNV) in the unaffected second eye of participants with eMNV in the first eye. Post hoc prognostic analysis on iAMD eyes from the prospective EDNA cohort.
Absolute chronology of the Early Palaeolithic Karatau Culture in Central Asia
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Abstract Central Asia represents a key region for our understanding of early human dispersal patterns, because it served as a migration corridor that linked the Levant and southern Caucasus with Northeast Asia. However, no Early Palaeolithic sites in Central Asia are anchored with reliable age constraints, including the thick loess-palaeosol sections in Tajikistan that recorded early human activities and environmental changes over multiple glacial-interglacial cycles.
By Aske L. Sørensen, Anton Anoikin, Kseniya A. Kolobova, Ekaterina Kulakova, Olga Meshcheryakova, Aljasil Chirakkal, Ramona Schneider, Vladimir Pavlov, Farhad Khormali, Andrew Murray, Jago J. Birk, Jesper Velgaard Olsen, Thomas Hansen, Thomas Stevens, David Wright, Jan-Pieter Buylaert, Mads F. Knudsen, Tura U. Khudjageldiev, Petr M. Sosin, Natalia Taratunina, Olga Tokareva, Amélie Challier, Asleddin Karayev, Islom Ashurmadov, Abdullo Sharipov, Andrei Rybalko, Gábor Ujvari, Redzhep N. Kurbanov
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Nature
Verified
Machine Learning to Predict Outcomes of Anti Vascular Endothelial Growth Factor Therapy in Neovascular Age Related Macular Degeneration
Key words Age-related macular degeneration machine learning optical coherence tomography anti-vascular endothelial growth factor visual acuity Abbreviations AI (Artificial intelligence) AMD (age-related macular degeneration) nAMD (neovascular age-related macular degeneration) anti-VEGF (anti–vascular endothelial growth factor) ML (machine learning) MNV (macular neovascularization) OCT (optical coherence tomography) VA (visual acuity) logMAR (logarithm of the minimum angle of resolution) SRF...
Why I worry the man-made climate change scam will never end
ON NOVEMBER 30, 2023, three eminent American climate scientists – Richard Lindzen Professor of Earth, Atmospheric, and Planetary Sciences, Emeritus Professor, Massachusetts Institute of Technology, William Happer, Professor of Physics, Emeritus Princeton University and Steven Koonin, University Professor, New York University – made a submission to the Court of Appeals in The Hague, the Netherlands, to support Shell against an organisation called Milieudefensie which claimed that the oil giant...
We’re about to lose our nuclear deterrent. Trump is quite justified in criticising our inadequate contribution to Nato
CASD stands for Continuous At Sea Deterrent. This defence strategy is executed for Britain by the Royal Navy’s four nuclear-powered, ballistic missile-armed submarines, SSBNs. But the CASD is now at severe risk of no longer being continuous. When HMS Resolution, the first of the bombers as the Navy calls them, went to sea in 1966, she and her sister boats’ patrols were limited to 60 days. Circling at three knots for weeks on end is the most boring form of seagoing the Navy has ever had to endure.
Forget the moon, Elon. Here’s where you should be spending your billions
IT WAS amazing to learn in a TCW article last month that Elon Musk’s fortune is more than double that of Jeff Bezos and Mark Zuckerberg combined. Which prompts the question: what is he doing with it? What he is actually doing is using his company, SpaceX, to build rockets for space exploration, including, ultimately, to colonise the moon in case Earth becomes uninhabitable.
The effects of housing temperature on mouse physiology and implications for disease modeling
Abstract Housing temperature has a critical role in preclinical research by affecting the physiological and metabolic responses of laboratory mice. Exposure to temperatures below the thermoneutral zone triggers adaptive responses, such as behavioral changes, increased energy expenditure and altered immune function, which can obscure experimental results and hinder the applicability of findings to the human physiology.
Author Correction: A consensus immune dysregulation framework for sepsis and critical illnesses - Nature Medicine
Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03956-5, published online 30 September 2025. In the version of the article initially published, Jeremiah Hinson (Department of Emergency Medicine, The Johns Hopkins University, Baltimore, MD, USA) was inadvertently omitted from the author list and contributions and has now been added to the HTML and PDF versions of the article.
A Stanza Analysis of Ninurta 1
Ayuda Buscar en la ayuda Buscar en la ayuda A Stanza Analysis of Ninurta 1 Tzvi Abusch [1] ; David P. Wright [1] [1] Brandeis University Localización: Revue d'assyriologie et d'archéologie orientale, ISSN 0373-6032, Nº. 118, 2024, págs. 143-150 Idioma: francés Enlaces Texto completo Resumen English In this study we provide a transcription, translation, and stanza analysis of Ninurta I.
Ibrutinib and rituximab versus immunochemotherapy in patients with previously untreated mantle cell lymphoma (ENRICH): a randomised, open-label, phase 2/3 superiority trial
Evidence before this study We searched PubMed from database inception to Jan 10, 2025, without language restrictions, for randomised phase 3 studies comparing the role of Bruton's tyrosine inhibitors with immunochemotherapy in the treatment of older patients with mantle cell lymphoma who were not eligible for transplantation.
A consensus immune dysregulation framework for sepsis and critical illnesses - Nature Medicine
Abstract Critical care syndromes such as sepsis, acute respiratory distress syndrome (ARDS) and trauma continue to have unacceptably high morbidity and mortality, with progress limited by the inherent heterogeneity within syndromic illnesses. Although numerous immune endotypes have been proposed for sepsis and critical care, the similarities and differences between these endotypes remain unclear, hindering clinical translation.
Clinical validation of an AI-based blood testing device for diagnosis and prognosis of acute infection and sepsis - Nature Medicine
Abstract Lack of reliable diagnostics for the presence, type and severity of infection in patients presenting to emergency departments with non-specific symptoms poses considerable challenges. We developed TriVerity, which uses isothermal amplification of 29 mRNAs and machine learning algorithms on the Myrna instrument to determine likelihoods of bacterial infection, viral infection and need for critical care interventions within 7 days.
China cashes in as Net Zero scam feeds the energy fat cats Original
The writer is in Australia THE reason that the climate crisis scam gravy train goes on and on is that an awful lot of people are making an awful lot of money from it. Two vivid examples: Orsted, the Danish firm which operates the North Sea wind farm Hornsea One, receives a guaranteed £200 per megawatt hour for its power, nearly three times current market prices. Since 2019, Hornsea One has received a staggering £2billion in top-up payments.
The enduring nature of wise counsel Original
SOME of these ‘thoughts’ are other people’s, some are my own, but I believe that they can all be helpful to any man or woman, young or old, who wants to lead a good and useful life. Do it now This was something my mother often said, and I have found many times that following it has been a very sensible thing to do. The most daunting tasks, whether physical or administrative (desk based), immediately become much less daunting and even quite easy once you’ve started them.
A deep learning system for detecting silent brain infarction and predicting stroke risk - Nature Biomedical Engineering
Abstract Current brain imaging to detect silent brain infarctions (SBIs) is not feasible for the general population. Here, to overcome this challenge, we developed a retinal image-based deep learning system, DeepRETStroke, to detect SBI and refine stroke risk. We use 895,640 retinal photographs to pretrain the DeepRETStroke system, which encodes a domain-specific foundation model for representing eye–brain connections.
Impact of Polygenic Risk Scores on Retinal Microstructures in Early and Intermediate Age-related Macular Degeneration: the Northern Ireland Sensory Aging Study | Eye
Abstract Although polygenic risk scores (PRSs) have been developed for age-related macular degeneration (AMD), it is not known whether these scores are associated with changes of retinal microstructures in early AMD. We compared retinal microstructures due to age-related changes in eyes with healthy macula in people aged 55 years or above versus those with early AMD and then determined the associations of retinal microstructural changes with AMD PRS.
Reasons to be proud of being British
FOR obvious reasons there are a lot of (justified) doom-mongering articles in TCW, not least some of my own. So, for a change, I have listed some of the many things Britain and the British should be immensely proud of. Here they are, in no particular order: Our beautiful countryside. Of the many examples, and all readers will have their own favourites, I single out Dartmoor, the last great wilderness in Britain.
Through the crystal ball: Forty ways life will get worse in the next ten years
1 Cash finally dies after long and intense lobbying by the banks so that they can reduce staff and premises and increase their obscene multi-billion-pound profits. 2 Banks disappear from the high street. All banking now done online. 3 Starmer has long ago stepped down. 4 Ed Miliband is PM. 5 Labour wins in 2029, Reform a distant second, Conservatives an even more distant third.
The no-nonsense way to stop the boats
ILLEGAL Channel crossings by rubber dinghies overloaded predominantly with young men have been an increasingly worrying trend for many years yet successive governments have made no serious or workable attempts to do anything about it. Migrant crossings are up by more than 40 per cent on last year and a record for daily arrivals has been set. A total of 705 migrants in 12 boats crossed the Channel on Tuesday April 15, days after the previous record of 656 was set the previous Saturday.
Why the gullible millions can’t see through the global warming hoax
IN HIS excellent article in TCW on March 27, which can be read here, Dr Shane Fudge gives many examples of how the man-made global warming hoax is promoted. Here I want to cover what I believe are the main factors that cause people to swallow the lies hook, line and sinker. It boils down to three principal factors. 1. Lack of common sense Or to be more accurate, the complete absence of common sense. This is a deficiency easily observed in the behaviour and speeches of politicians.
Correction: Polygenic Risk Score Impact on Visual Function in Older Individuals with Healthy Macula: The Northern Ireland Sensory Ageing Study - Eye
Correction to: Eye https://doi.org/10.1038/s41433-025-03642-3, published online 17 February 2025 In this article the article title has been updated from “Polygenic Risk Score Impact Visual Function in Healthy: The Northern Ireland Sensory Ageing Study” to “Polygenic Risk Score Impact on Visual Function in Older Individuals with Healthy Macula: The Northern Ireland Sensory Ageing Study”. The original article has been corrected. About this article Tang, F., Hogg, R.E., Higgins, B.E. et al.
CD8 T lymphocytes redeploy embryonic cell cycle control mechanisms to facilitate rapid cell proliferation
Abstract Rapid proliferation and expansion of cytotoxic CD8 T lymphocytes is crucial for adaptive immunity against viral infection. CD8 T cell cycles complete cell division cycles in <6 hours, representing a physiological extreme for somatic mammalian cells. Embryonic stem cells also rapidly divide and have been shown to utilize specialized cell cycle control mechanisms that differ from somatic fibroblasts, including subdued periodicity of cyclin proteins.
AI for glaucoma, Are we reporting well? a systematic literature review of DECIDE-AI checklist adherence - Eye
Abstract This systematic literature review examines the quality of early clinical evaluation of artificial intelligence (AI) decision support systems (DSS) reported in glaucoma care. Artificial Intelligence applications within glaucoma care are increasing within the literature. For such DSS, there needs to be standardised reporting to enable faster clinical adaptation. In May 2022, a checklist to facilitate reporting of early AI studies (DECIDE-AI) was published and adopted by the EQUATOR network.
Polygenic risk score impact visual function in healthy: the Northern Ireland Sensory Ageing study - Eye
Abstract Although polygenic risk scores (PRSs) have been developed for age-related macular degeneration (AMD), it is not known whether these scores are associated with impairment of visual functions in older individuals with healthy macula. We evaluated age-related changes in visual function in people aged 55 years or above with healthy macula and determined the associations of age-related visual function changes with AMD PRS in people with healthy macula.
Miliband sacrifices Britain to his global warming god - The Conservative Woman
THE TOTAL DESTRUCTION of Great Britain is well under way and proving a highly successful venture, thanks to one man and one man alone: Ed Miliband. Given free rein by Sir Keir Starmer, Miliband has been religiously concreting fracking wells, shutting down North Sea oil and gas exploration, and enthusiastically acceding to a misguided and out-of-order judge who has banned the expansion of two important North Sea oil fields, Jackdaw and Rosebank.
Intensified monsoonal rainstorm events over westerly-dominated Asian interior during the warm mid-Holocene - Communications Earth & Environment
Abstract Hydroclimatic change in the Asian interior plays a key role in regulating regional environmental sustainability, water security, and human-nature relationships. However, the influence of the summer monsoon and westerly circulation on the evolution of hydroclimate over the arid Asian interior remains controversial.
Stone Age anthropogenic impacts to forest development in the interior Scandinavian Peninsula
Abstract Forest growth and development is a highly studied phenomenon in which humans have proven to be influential in shaping structure and composition. Delineating the long-term processes of human-environment interactions is crucial for understanding the history and trajectory of landscape formation and vegetation development. Yet, extensive knowledge of the ecological impacts of Stone Age anthropogenic activity is still lacking, particularly from Fennoscandian sites.
Visual Acuity Outcomes and Influencing Factors in a Cohort of UK Real-World Diabetic Macular Oedema Patients During the First Two Years of Anti-VEGF Treatment
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
An idiot’s guide to cutting CO2 (alas, the idiots are in charge)
RECENTLY appointed by Sir Keir Starmer as Minister of State for Food Security and Rural Affairs, Daniel Zeichner has no background or experience of farming. So, among others, he will have no idea of the impact of onshore wind farms and solar farms on food-producing land. Politicians have to be seen to be doing something in response to any scare, manufactured or real; covid being a classic example. So what is their response to the grifters who say that CO2 causes the Earth to warm?
Why I despair that the ‘global warming’ scam will ever be recognised as such
THE AGENDA for the Commonwealth Heads of Government Meeting (CHOGM) just ended in Samoa was dominated by three items: climate change, sea levels and colonialism. Samoa is right in the middle of the south Pacific. It would be reasonable to think the agenda would at least have been primarily concerned with security and defence in view of China’s aggression in the region, and also economic growth, health and infrastructure development.
The oceans are boiling and other tall stories
‘The oceans are boiling,’ said the world-famous climate scientist Al Gore. ‘The world is on fire,’ said the world-famous climate scientist Prince Harry. ‘It’s code red for humanity,’ said the world-famous climate scientist António Guterres. ‘The earth has a fever and it is sick,’ said the world-famous climate scientist Pope Francis.
Labour’s Spoilsport Tendency
VINDICTIVE as ever, the Labour government plans to ban trail hunting, which is the pursuit of a (consenting) man or woman over the countryside by a small pack of bloodhounds. It is the only remaining legal form of hunting. On what possible grounds can trail hunting be condemned other than pure spoilsporting? But then the Labour Party has a long history of being spoilsports.
Exploratory Investigation of Head Stability in Children with Cerebral Palsy and Typically Developing Children during a Targeted Stepping Task
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Dark, cold and hopeless – a glimpse of life five years from now - The Conservative Woman
IT’S 2029 and Prime Minister Sir Keir Starmer is expected to announce the date of the general election shortly. He has no worries because he knows, and the polls and pundits in the media are constantly telling him, that he will have an easy win with a very low turnout because what is left of the Conservative Party have not announced any positive growth policies and are still bickering over a third replacement candidate for the leadership.
A cup of coffee can boost your motor performance: Enhanced motor sequence learning with caffeine
Abstract Caffeine is consumed in various beverages, such as coffee, energy drinks, soda, and tea. The effects of caffeine have been shown to manifest in various ways across different studies. Some studies suggest that caffeine can enhance motor performance. Despite this, numerous motor learning studies do not control for participants' caffeine intake or do not record whether participants consumed caffeine.
The road to Net Zero goes round the bend
The writer is in Australia LET ME start by saying that all the wind farms, solar farms and electric vehicles in the entire world are a waste of time, space and, above all, money. Why? Two reasons. First and foremost because carbon dioxide in the atmosphere has zero influence on the world’s climate, as has been unequivocally proved by real, empirical, historical evidence from Antarctic ice cores, lake sediments and other unimpeachable geological sources.
The complexity of caring for dying residents cannot be understated, nor can its moral significance
hospice and palliative care nursing ethics nursing theory Commentary on: Gilbert R, Lillekroken D. Caring to the end: an empirical application of Swanson’s caring theory to end-of-life care. ANS Adv Nurs Sci. 2023 Oct 13. doi: 10.1097/ANS.0000000000000515. Epub ahead of print. Nursing theories, like Swanson’s caring theory, can bring visibility to the knowledge and skill harnessed by nurses when caring for dying patients and their families.
Reform is the only option
SINCE the general election was announced, the Daily Telegraph and other right-leaning print media have been replete with articles from journalists and past and present Tory MPs and ministers urging us to vote Conservative to avoid or reduce a catastrophic defeat (and coincidentally to keep their jobs). These articles will continue right up to polling day, but they are pointless and without merit.
The tragedy of Net Zero for the world’s poor
IT HAS been calculated that the West spends half a trillion dollars a year on the futile attempt to ameliorate the non-existent effects of the global warming catastrophe hoax. I suspect that it is considerably more than that.
Daft climate zealots with ever more money to burn
The writer is in Australia. THE recently released Climate the Movie featured on TCW over the first week on April devoted one of its sections to what is known as the climate consensus – its funding to the tune of billions for climate research for which ‘academics of every kind lined up . . . an exciting new area of interest for sociologists, biologists, professors of English literature, lecturers in gender studies, and many more’.
IJERPH | Free Full-Text | Spatio-Temporal Variation in the Exceedance of Enterococci in Lake Burley Griffin: An Analysis of 16 Years’ Recreational Water Quality Monitoring Data
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Generalization in motor learning: learning bimanual coordination with one hand
Abstract The ability to coordinate movements between the hands is crucial for many daily tasks. However, the precise mechanisms governing the storage and utilization of bimanual movement and the distinct contributions of each limb in this process are currently not fully understood. Two key questions persist: 1) How is the neural representation of bimanual coordination stored in the brain, and 2) How is the information governing bimanual coordination shared between hemispheres?
Biosynthesis, Engineering, and Delivery of Selenoproteins
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Marine invertebrates as proxies for early kelp use along the western coast of South America
Introduction Algae have been important for people since ancient times. The kelp highway hypothesis for early human peopling routes into the American continents is one example (Erlandson et al., 2007). The marine route goes along the productive coastal ecosystems provided by giant Kelp (Macroystis pyrifera) forests; the use of kelp environments by early humans is evidenced in the profuse nearshore resources present in late Pleistocene–early Holocene sites along the Eastern Pacific shores.
M1 recruitment during interleaved practice is important for encoding, not just consolidation, of novel skill memory
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
Age and adult attachment style predict psychological distress in the Singapore general population during COVID-19
Skip to main page content Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Save citation to file Format: Add to My Bibliography Your saved search Name of saved search: Search terms: Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Create a file for external citation management software doi: 10.1080/13548506.2023.2216466. Online ahead of print.
The 'Care homes independent prescriber study': lessons learned for practitioners and researchers
The ‘Care homes independent pharmacist prescriber study’ (CHIPPS), published in the BMJ on 14 February 2023, built on the findings of several existing research papers. The ‘Care homes’ use of medicines study’ (CHUMS) had already clearly demonstrated the need for better medicines management in care homes and resulted in a government request for interventions to address it[1,2].
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