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Articles by De Marzo
Computer Science > Computation and Language
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Divergent effects of PLA2G7 on prostate cancer biochemical recurrence in European American and African American men Open Access
Disparities in prostate cancer in the United States are noteworthy, with African American (AA) men having incidence rates 1.8 times as high as European American (EA) men and mortality more than twice as high.1 Unequal access to medical treatment plays a role in explaining some of these differences,2-4 and evidence is accumulating that when equal treatment is administered to AA and EA patients with the same stage and grade of prostate cancer, AA patients have outcomes equal to or superior to...
Androgen Receptor Drives Polyamine Synthesis, Creating a Vulnerability for Prostate Cancer
Supraphysiologic androgen (SPA) treatment can paradoxically restrict the growth of castration-resistant prostate cancer (CRPC) with high androgen receptor (AR) activity, which is the basis for the use of bipolar androgen therapy (BAT) for patients with this disease. Although androgens are widely appreciated for enhancing anabolic metabolism, how SPA-mediated metabolic changes alter prostate cancer progression and therapy response is unknown.
[2601.05384] Conformity and Social Impact on AI Agents
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer
Supraphysiological androgen (SPA) treatment can paradoxically restrict growth of castration-resistant prostate cancer with high androgen receptor (AR) activity, which is the basis for use of Bipolar Androgen Therapy (BAT) for patients with this disease. While androgens are widely appreciated to enhance anabolic metabolism, how SPA-mediated metabolic changes alter prostate cancer progression and therapy response is unknown.
The Collective Turing Test: Large Language Models Can Generate Realistic Multi-User Discussions
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
La certezza del diritto nel prisma dell'applicazione giurisprudenziale: quando è necessario estremo rigore nell'esame dei casi e nella definizione delle categorie concettuali.: (Nota a Cass. 26 marzo -16 luglio 2024, n. 28594, Boenzi)
Ayuda Buscar en la ayuda Buscar en la ayuda La certezza del diritto nel prisma dell'applicazione giurisprudenziale: quando è necessario estremo rigore nell'esame dei casi e nella definizione delle categorie concettuali.: (Nota a Cass. 26 marzo -16 luglio 2024, n. 28594, Boenzi) Autores: Giuseppe De Marzo Localización: Il Foro Italiano, ISSN 0015-783X, ISSN-e 1827-8213, Vol. 149, Nº.
SPOT: spatial proteomics through on-site tissue-protein-labeling - Clinical Proteomics
SPOT is designed to provide quantitative deep profiling of spatially-resolved proteomics by direct TMT labeling tissue proteins on slides (Fig. 1). Isobaric labeling with TMT is used as a proof-of-principle study, TMT is a well-established robust system [45] for multiplex, relative protein quantitation of up to 18 samples. TMT binds to primary amines (N-terminal and epsilon amino group of lysine residues) in proteins/peptides using NHS chemistry [46].
Brevi note in tema di riforma dei reati fallimentari (parte Il)
IdiomacatalàDeutschEnglishespañoleuskarafrançaisgalegoitalianoportuguêsromână
Brevi note in tema di riforma dei reati fallimentari (parte I)
IdiomacatalàDeutschEnglishespañoleuskarafrançaisgalegoitalianoportuguêsromână
Questioni controverse in tema di esercizio dell'azione civile in sede penale
IdiomacatalàDeutschEnglishespañoleuskarafrançaisgalegoitalianoportuguêsromână
Prenatal Management and Perinatal Outcome in a Large Series of Hydrops Fetalis
Introduction: Nonimmune hydrops fetalis (NIHF) is the most frequent etiology of hydrops fetalis (HF), accounting for around 95% of cases. It associates high perinatal mortality and morbidity rates. The aim of the study was, first, to investigate etiology, prenatal management, and perinatal outcome in a large single-center series of HF; second, to identify prenatal prognostic factors with impact on perinatal outcome.
La tutela penale dell'ambiente in ambito eurounitario (la direttiva 11 aprile 2024 n. 2024/1203 del parlamento europeo e del consiglio)
Ayuda Buscar en la ayuda Buscar en la ayuda La tutela penale dell'ambiente in ambito eurounitario (la direttiva 11 aprile 2024 n. 2024/1203 del parlamento europeo e del consiglio) Autores: Giuseppe De Marzo Localización: Il Foro Italiano, ISSN 0015-783X, ISSN-e 1827-8213, Vol. 149, Nº. 7-8, 2024 Idioma: italiano Texto completo no disponible (Saber más ...)
Anticancer Effects of the Trivalent Organoarsenical 2-Amino-4-(dihydroxyarsinoyl) Butanoate
Cancer is the second-leading cause of death in the United States, behind only heart disease, and breast cancer is the second-leading cause of death for women. (1) Breast cancer has historically been subclassified by three molecular markers: estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (EGFR2/Her2), all of which contribute to the prognosis and choice of treatment.
La disciplina processuale di attuazione del regolamento Ue n. 1805 del 2018 in tema di riconoscimento reciproco dei provvedimenti di congelamento e confisca (d.leg. 7 dicembre 2023
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Brevi note in tema di attuazione delle sentenze della Corte di Strasburgo (art. 628 bis c.p.p.) (Nota a Cass. 12 ottobre - 23 novembre 2023, n. 47183, K.) - Dialnet
IdiomacatalàDeutschEnglishespañoleuskarafrançaisgalegoitalianoportuguêsromână
The Tully–Fisher relation and the Bosma effect
The rotation curves of spiral galaxies appear to be roughly flat out to the outermost observed points, which is in contrast to the nearly Keplerian decline expected from the luminous disc (see e.g. Rubin, Ford & Thonnard 1980 and Sancisi 1999 and references therein). This discrepancy has led to the conclusion that spiral galaxies are dominated by a massive dark halo which has a different nature from the luminous matter.
Supraphysiological Androgens Promote the Tumor Suppressive Activity of the Androgen Receptor through cMYC Repression and Recruitment of the DREAM Complex
The signaling program regulated by the androgen receptor (AR) is an important therapeutic target for the treatment of metastatic prostate cancer (mPC) as it mediates critical cell survival, proliferation, and metabolic functions (1, 2). Treatment strategies center on suppressing AR signaling, either by androgen deprivation therapy (ADT), and/or administering AR signaling inhibitors (ARSI) including competitive antagonists (3–6).
Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer
Glutathione S-transferase pi 1 (GSTP1) is lowly expressed in normal prostate luminal cells and becomes induced in most proliferative inflammatory atrophy (PIA) lesions. GSTP1 becomes silenced in prostatic intraepithelial neoplasia (PIN) and prostate adenocarcinoma (CaP) via cytosine-phospho-guanine (CpG) island promoter hypermethylation. However, GSTP1 methylation patterns in PIA and PIN, and their relationship to patterns in CaP are poorly understood.
[2307.06147] The dynamics of higher-order novelties
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Mapping non-axisymmetric velocity fields of external galaxies
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Progressive spreading of DNA methylation in the GSTP1 promoter CpG island across transitions from precursors to invasive prostate cancer
Glutathione S-transferase pi 1 (GSTP1) is lowly expressed in normal prostate luminal cells and becomes induced in most proliferative inflammatory atrophy lesions (PIA). GSTP1 becomes silenced in prostatic intraepithelial neoplasia (PIN) and prostate adenocarcinoma (CaP) via cytosine-phospho-guanine (CpG) island promoter hypermethylation. However, GSTP1 methylation patterns in PIA and PIN, and their relationship to patterns in CaP are poorly understood.
L’urgente bisogno di un’alternativa civilizzante
IdiomacatalàDeutschEnglishespañoleuskarafrançaisgalegoitalianoportuguêsromână
Il disegno di legge di contrasto alla violenza domestica (Nota a Cass. 13 gennaio - 2 febbraio 2023, n. 4572, B.)
IdiomacatalàDeutschEnglishespañoleuskarafrançaisgalegoitalianoportuguêsromână
La disciplina in materia di impugnazioni penali nella riforma Cartabia (d.leg. 10 ottobre 2022 n. 150)
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SOX2 mediates metabolic reprogramming of prostate cancer cells - Oncogene
Abstract New strategies are needed to predict and overcome metastatic progression and therapy resistance in prostate cancer. One potential clinical target is the stem cell transcription factor SOX2, which has a critical role in prostate development and cancer. We thus investigated the impact of SOX2 expression on patient outcomes and its function within prostate cancer cells.
La corte di Strasburgo e il c.d. principio di autosufficienza dinanzi alla Cassazione penale (Nota a Corte eur. diritti dell’uomo 28 ottobre 2021, Succi)
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Castration-mediated IL-8 promotes myeloid infiltration and prostate cancer progression - Nature Cancer
Abstract Unlike several other tumor types, prostate cancer rarely responds to immune checkpoint blockade (ICB). To define tumor cell intrinsic factors that contribute to prostate cancer progression and resistance to ICB, we analyzed prostate cancer epithelial cells from castration-sensitive and -resistant samples using implanted tumors, cell lines, transgenic models and human tissue.
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