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Efficacy of a 1% ibuprofen nanostructured topical gel in reducing in-office bleaching sensitivity following 35% hydrogen peroxide application: a randomized, controlled, triple-blind, split-mouth clinical trial | Clinical Oral Investigations

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By de Barros Oliveira, Francisca Duarte, Bárbara Martins Faria, de Sá Barbosa
| link.springer.com
Abstract This study aimed to evaluate the efficacy of a 1% ibuprofen nanostructured topical gel in controlling in-office bleaching sensitivity (BS) and its impact on tooth color change. A randomized, controlled, triple-blind, split-mouth clinical trial was conducted with 40 participants. The nanostructured ibuprofen gel (I) and placebo (P) were applied for 10 min before and after bleaching (35% hydrogen peroxide; 1 × 50 min; two sessions, one week apart) on each hemi-arch, randomly assigned.
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