Deao Xu

Abstract Precise control over the presence and position of knots in polymers remains a long-standing synthetic challenge, with theory indicating broad implications for properties and function. Here we report on a topological synthon approach—extension and macrocyclization of an overhand knot—that enables the high yielding synthesis of closed-loop trefoiled polymers with narrow polydispersity and tunable topological parameters.

Abstract Click to copy section linkSection link copied! Polymer mechanochemistry enables control over the chemical reactivity through defined force-loading geometries. However, in most mechanophores, force is transmitted through only two loading points, which confines reactivity to a single dominant pathway and limits the diversity of mechanically accessible outcomes.