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Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery
1 Introduction Bringing a new drug to market heavily depends on efforts put into preclinical research. The preliminary data on a drug's toxicity, efficacy, and safety were primarily obtained through animal experiments. However, over the last few decades, regulatory and funding agencies have made continuous efforts to reduce reliance on animals for preclinical drug safety and efficacy testing [1, 2].
Hyperglycemia-induced P300/CBP acetyltransferase drives ZEB2-mediated pro-inflammatory macrophages and delays wound healing
ResearchDermatologyImmunologyInflammation Open Access | 10.1172/jci.insight.192146 JCI Insight. https://doi.org/10.1172/jci.insight.192146. Copyright © 2026, Roy et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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