Debashree Chatterjee

Abstract The HIV-1 envelope glycoprotein (Env) is expressed at the surface of infected cells and as such can be targeted by non-neutralizing antibodies (nnAbs) that mediate antibody-dependent cellular cytotoxicity (ADCC). Previous single-molecule Forster resonance energy transfer (smFRET) studies demonstrated that Env from clinical isolates predominantly adopt a 'closed' conformation (State 1), which is resistant to nnAbs.

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by 1,2, 1, 1, 1, 1,2, 1,2, 1,2, 1, 1, 1, 1, 1,2,* and 1,2,* 1 Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada 2 Université de Montréal, Département de Microbiologie, Infectiologie et Immunologie, Montreal, QC H3C 3J7, Canada * Authors to whom correspondence should be addressed.

Alexandra Tauzin, Shang Yu Gong, Mark M. Painter, View ORCID ProfileRishi R. Goel, Debashree Chatterjee, Guillaume Beaudoin-Bussières, Lorie Marchitto, Marianne Boutin, Annemarie Laumaea, James Okeny, Gabrielle Gendron-Lepage, Catherine Bourassa, Halima Medjahed, Guillaume Goyette, Justine C. Williams, Yuxia Bo, Laurie Gokool, Chantal Morrisseau, Pascale Arlotto, Renée Bazin, Judith Fafard, Cécile Tremblay, Daniel E.