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Deepak Bararia on Muck Rack

Deepak Bararia

As seen in: BioRxiv, Cell Reports
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Articles

ARID1A Mutations Protect Follicular Lymphoma from FAS-dependent Immune Surveillance by Reducing RUNX3/ETS1-Driven FAS-Expression

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By Martina Antoniolli, Carolin Dorothea Strobl, Deepak Bararia, Maria Solovey
| BioRxiv
Abstract The cell death receptor FAS and its ligand (FASLG) play crucial roles in the selection of B cells during the germinal center (GC) reaction. Failure to eliminate potentially harmful B cells via FAS can lead to lymphoproliferation and the development B cell malignancies. The classic form of follicular lymphoma (FL) is a prototypic GC-derived B cell malignancy, characterized by the t(14;18)(q32;q21)IGH::BCL2 translocation and overexpression of antiapoptotic BCL2.
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Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma

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By Deepak Bararia, Johannes A. Hildebrand, Sebastian Stolz, Sarah Haebe
| Cell Reports Verified
Highlights • CTSS hyperactivity through mutations or overexpression in ∼20% of FL • CTSS mutations cluster at Y132 and accelerate autocatalytic cleavage and activation • CTSS hyperactivity increases CD4+ T cell activation and accelerates tumor growth in vivo • Higher activity of immunosuppressive immunochemotherapy in CTSS-hyperactive human FL Summary Tumor cells orchestrate their microenvironment.
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