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Deepanwita Bose

As seen in: Nature, BioRxiv
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Articles

Publisher Correction: TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo - Nature Communications

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By Deepanwita Bose, Yogesh Goyal, James Arthos, Brandon F. Keele, Monica Vaccari, Ramon Lorenzo-Redondo, Thomas J. Hope
| Nature Verified
Correction to: Nature Communications https://doi.org/10.1038/s41467-024-45555-x, published online 14 February 2024 The original version of the Peer Review File associated with this Article was updated after publication to redact the name of a researcher who prefers to remain anonymous. The file has been corrected.
Open in Who Shared View Duplicates (8) Issue with article?

TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo - Nature Communications

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By Deepanwita Bose, Yogesh Goyal, James Arthos, Brandon F. Keele, Monica Vaccari, Ramon Lorenzo-Redondo, Thomas J. Hope
| Nature Verified
Abstract HIV-1 persistence during ART is due to the establishment of long-lived viral reservoirs in resting immune cells. Using an NHP model of barcoded SIVmac239 intravenous infection and therapeutic dosing of anti-TGFBR1 inhibitor galunisertib (LY2157299), we confirm the latency reversal properties of in vivo TGF-β blockade, decrease viral reservoirs and stimulate immune responses.
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TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo

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By Mariluz Araínga, Jinhee Kime, Deepanwita Bose, Muhammad R Haque
| BioRxiv
Abstract HIV-1 persistence during ART is due to the establishment of long-lived viral reservoirs in resting immune cells. Using an NHP model of barcoded SIVmac239 intravenous infection and therapeutic dosing of the anti-TGFBR1 inhibitor galunisertib (LY2157299), we confirmed the latency reversal properties of in vivo TGF-β blockade, decreased viral reservoirs and stimulated immune responses. Eight SIV-infected macaques on suppressive ART were treated with 4 2-week cycles of galunisertib.
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