Dejie Wang

1. Introduction With the rapid development of advanced manufacturing technologies, it is necessary to improve the machining performance and quality for industrial purposes [1,2,3]. The high-speed metal circular sawing machine is a marvel of efficiency and precision, deftly slicing through steel and non-ferrous metals with ease. Its widespread use in metallurgy and manufacturing is a testament to its versatility and effectiveness.

Abstract 53BP1 activates nonhomologous end joining (NHEJ) and inhibits homologous recombination (HR) repair of DNA double-strand breaks (DSBs). Dissociation of 53BP1 from DSBs and consequent activation of HR, a less error-prone pathway than NHEJ, helps maintain genome integrity during DNA replication; however, the underlying mechanisms are not fully understood.

The bromodomain and extra-terminal domain (BET) protein BRD4 is emerging as a promising anticancer therapeutic target. However, resistance to BET inhibitors often occurs, and it has been linked to aberrant degradation of BRD4 protein in cancer. Here, we demonstrate that the deubiquitinase DUB3 binds to BRD4 and promotes its deubiquitination and stabilization. Expression of DUB3 is transcriptionally repressed by the NCOR2-HDAC10 complex.