Deng Ying
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UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins
eLife Assessment This important manuscript demonstrates that UGGT1 is involved in preventing the premature degradation of endoplasmic reticulum (ER) glycoproteins through the re-glucosylation of their N-linked glycans following release from the calnexin/calreticulin lectins.
UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins
Abstract How the fate (folding versus degradation) of glycoproteins is determined in the endoplasmic reticulum (ER) is an intriguing question. Monoglucosylated glycoproteins are recognized by lectin chaperones to facilitate their folding, whereas glycoproteins exposing well-trimmed mannoses are subjected to glycoprotein ER-associated degradation (gpERAD); we have elucidated how mannoses are sequentially trimmed by EDEM family members (George et al., 2020, 2021 eLife).
基于Nrf-2/ HO-1 探究甘草锌对黄褐斑小鼠的治疗作用
Abstract: Objective To investigate the therapeutic effect of licorice zinc on melasma. Methods Thirty-six BALB/ c mice were equally divided into blank group, model group, licorzinc low-dose group, licorzinc medium-dose group, licorzinc high-dose group and tranexamic acid group. Melasma was induced by 100 mJ/ cm2 UVB irradiation combined with 15 mg/ kg progesterone injection. Mice were treated with tranexamic acid (0. 065 g/ kg) and low (0. 65 g/ kg), medium(1. 3 g/ kg), or high (2.
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