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A novel, centrally acting mammalian aminosterol, ENT‐03, induces weight loss in obese and lean rodents
1 INTRODUCTION Trodusquemine (MSI-1436; Figure 1) was discovered during the isolation and characterization of novel amino steroids present in the liver of the dogfish shark.1 It was subsequently demonstrated that trodusquemine induces profound metabolic effects in several vertebrate species, including humans.
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