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Dennis Alexander Agardy on Muck Rack

Dennis Alexander Agardy

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Articles

VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells

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By Thomas Kerzel, Jonas Bergh, Dennis Alexander Agardy, Anna Malmerfeldt
| Cell Reports Verified
Highlights • VEGF-C from TAMs increases metastases in the lymph nodes compared with the lungs • VEGF-C-expressing TAMs increase tumor vessel normalization and reduce hypoxia • Enforced expression of VEGF-C in TAMs enhances expression of podoplanin • Inverse association between VEGF-C-expressing TAMs and breast cancer progression Summary The expression of pro-lymphangiogenic VEGF-C in primary tumors is associated with sentinel lymph node metastasis in most solid cancer types.
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