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Deophine Ngosa

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Articles

Restoration of anti-bacterial innate immune cell function lags behind nutritional recovery among children convalescing from complicated severe acute malnutrition

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By Sandra Rukobo, Kuda Mutasa, Tracy N. Phiri, Margaret Govha, Patience Mushayanembwa, Simutanyi Mwakamui, Tafhima Haider, Ellen Besa, Kanekwa Zyambo, Cherlynn Dumbura, Joice Tome, Thompson Runodamoto, Florence Majo, Deophine Ngosa, Kanta Chandwe, Chanda Kapoma, Jonathan P Sturgeon, Ruairi Robertson, Kusum J Nathoo, Melanie Smuk, Robert Ntozini, Beatrice Amadi, Paul Kelly, Mutsa Bwakura-Dangarembizi, Andrew J Prendergast, Claire D Bourke
| Nature Verified
Abstract Children recovering from complicated severe acute malnutrition (SAM) have a high risk of infectious mortality and morbidity, which could reflect impaired anti-microbial defence. We used blood samples from a cross-sectional cohort of children under 5 years’ old admitted to hospital with SAM in Zambia and Zimbabwe (cases, n = 125) and adequately nourished non-hospitalised children from the same communities (controls, n = 73) to characterise anti-bacterial innate immune cell function.
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