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Claire D Bourke on Muck Rack

Claire D Bourke

As seen in: Nature, The Independent (UK), BMJ Open, Gut Journal, The Conversation, Science Magazine, Medical Xpress, The Lancet, Times of Malta, Healio and
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Articles

Restoration of anti-bacterial innate immune cell function lags behind nutritional recovery among children convalescing from complicated severe acute malnutrition

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By Sandra Rukobo, Kuda Mutasa, Tracy N. Phiri, Margaret Govha, Patience Mushayanembwa, Simutanyi Mwakamui, Tafhima Haider, Ellen Besa, Kanekwa Zyambo, Cherlynn Dumbura, Joice Tome, Thompson Runodamoto, Florence Majo, Deophine Ngosa, Kanta Chandwe, Chanda Kapoma, Jonathan P Sturgeon, Ruairi Robertson, Kusum J Nathoo, Melanie Smuk, Robert Ntozini, Beatrice Amadi, Paul Kelly, Mutsa Bwakura-Dangarembizi, Andrew J Prendergast, Claire D Bourke
| Nature Verified
Abstract Children recovering from complicated severe acute malnutrition (SAM) have a high risk of infectious mortality and morbidity, which could reflect impaired anti-microbial defence. We used blood samples from a cross-sectional cohort of children under 5 years’ old admitted to hospital with SAM in Zambia and Zimbabwe (cases, n = 125) and adequately nourished non-hospitalised children from the same communities (controls, n = 73) to characterise anti-bacterial innate immune cell function.
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Why ceremonial cacao is the pure chocolate experience you need to try

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By Claire D Bourke, Tianna Nadalin, Michelle Rose
| House of Wellness Verified
Ceremonial cacao is the ultimate upgrade for chocolate lovers. But what is it and how can it transform your sweet cravings into a health-boosting ritual? Whether you are treating yourself to a deliciously rich piece of dark chocolate or cosying up with a cup of hot cocoa on a chilly winter night, chocolate has long been lauded for its ability to soothe the soul and lift your spirits. But what if you could take your chocolate fix to the next level?
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Inflammation and cytomegalovirus viremia during pregnancy drive sex-differentiated differences in mortality and immune development in HIV-exposed infants | Nature Communications

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By Ceri Evans, Ethan K Gough, Paul Kelly, Claire D Bourke, Robert Ntozini, Christie Noble
| Nature Verified
Abstract Children who are HIV-exposed but uninfected have increased infectious mortality compared to HIV-unexposed children, raising the possibility of immune abnormalities following exposure to maternal viraemia, immune dysfunction, and co-infections during pregnancy. In a secondary analysis of the SHINE trial in rural Zimbabwe we explored biological pathways underlying infant mortality, and maternal factors shaping immune development in HIV-exposed uninfected infants.
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