Deriggio Faicchia on Muck Rack

Deriggio Faicchia

As seen in: Cell Press
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Articles

Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential

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By Claudio Procaccini, Silvia Garavelli, Fortunata Carbone, Dario Di Silvestre, Claudia La Rocca, Dario Greco, Alessandra Colamatteo, Maria Lepore, Claudia Russo, Giusy De Rosa, Deriggio Faicchia, Francesco Prattichizzo, Sarah Grossi, Paola Campomenos
| Cell Press Verified
Highlights • SLC7A11 controls Treg cell proliferation induced by signals of pseudo-starvation • SLC7A11 coordinates the antioxidant response in proliferating Treg cells • Growth-defective Treg cells from RRMS patients fail to induce SLC7A11 • DMF therapy restores Treg cell proliferation, inducing SLC7A11 in RRMS patients Summary Human CD4+CD25hiFOXP3+ regulatory T (Treg) cells are key players in the control of immunological self-tolerance and homeostasis.
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