Devikala Gurusamy

Highlights • Expansion, memory, and oxidative and genomic stress define effective anti-tumor T cells • Multi-phenotype CRISPR-Cas9 screen reveals functional role of TCR-driven kinases • p38 regulates memory, redox homeostasis, and anti-tumor function of T cells • p38 is established as a target for improving TCR and CAR adoptive T cell therapies Summary T cells are central to all currently effective cancer immunotherapies, but the characteristics defining therapeutically effective anti-tumor T...

Extrathymic T Cells Derived from iPSCs by OP9/DLL1 Displayed Markers of Immature T Lineage Cells and Innate-like Immune Cells iTEs Launch a Functional T Cell Program Analogous to that of Post-thymic Mature CD8+ T Cells Small Numbers of iTEs Suppress Growth of Established Tumors and Prolong the Survival of Tumor-Bearing Animals Generation of iPSCs, Maintenance, and Differentiation into T Lineage Cells We hypothesized that the restoration of physiological thymic signaling could induce in vitro...