Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Abstract The cyclin-dependent kinase CDK11 is an understudied kinase that has been the subject of conflicting reports regarding its function in cancer. Here, we combine genetic and pharmacological approaches to demonstrate that CDK11 is a critical regulator of cancer cell survival that is required for RNA splicing and the expression of homologous recombination genes.
Highlights • Periods of chromosomal instability can accelerate acquisition of drug resistance • Drug-resistant cancer cells frequently harbor recurrent aneuploidies • Recapitulation of an aneuploidy in drug-naive cells is sufficient for resistance • Chromosomal instability correlates with poor therapeutic responses in human tumors Summary Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy typically antagonizes cellular fitness.
Highlights Aneuploidy and CIN are better predictors of cancer patient mortality than mutations in most oncogenes and tumor suppressors. Chromosome copy number changes are strongly associated with drug resistance both in vitro and in vivo. The experimental induction of CIN accelerates the ability of cells to evolve in response to selective pressure. New sequencing and imaging technologies make the routine assessment of aneuploidy and CIN in patient samples more feasible.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
