Devorah Vanness

Abstract Miniaturized microscopes or ‘miniscopes’ for neuroimaging in freely behaving animals mostly operate over short durations (<2 h) and image either neuronal activity or cerebral hemodynamics. In contrast, central nervous system (CNS) disease models involving seizures, brain tumors etc.

Highlights • Knockdown or deletion of postsynaptic MEF2 blocks the late phase of cerebellar LTD • Purkinje cells transfected with active MEF2 show normal synaptic strength • Activation of MEF2 is necessary, but not sufficient, for the late phase of LTD Summary The MEF2 family of transcription factors restricts excitatory synapse number in an activity-dependent fashion during development, yet MEF2 has not been implicated in long-term synaptic depression (LTD), which is thought to initiate...