Dhwani Dholakia

Abstract The translation of complex cancer genomics into clinically actionable insights is a critical bottleneck in precision oncology. To automate the entire workflow, we present OncoGen.AI, an end-to-end, containerized platform that automates the process from raw sequencing data to a final clinical report. The platform integrates platform-agnostic pipelines (Illumina/Ion Torrent) for variant calling, copy number variation (CNV), and tumor mutational burden (TMB) analysis.

Abstract Thermophilic organisms have evolved a proteome that resists thermal denaturation. While the evolution of their complete proteome would require multiple generations, early on, organisms would need to develop strategies to survive at high temperatures despite their thermolabile proteome. We hypothesized that the organisms would do this by reinforcing their proteostasis capacity.