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Articles by Di Long
Efficacy of the Bispecific Anti-BAFF/IL-21 Antibody CZ105 Bis2 in Models of Systemic Lupus Erythematosus
Supporting Information Filename Description art70310-sup-0001-Disclosureform.pdfPDF document, 693.1 KB Data S1: Disclosureform art70310-sup-0002-Supinfo.docxWord 2007 document , 10.1 MB Data S2: Supinfo
Predicting comorbidities in psoriasis using TCM constitution and multimodal data: a prospective cohort study protocol
Abstract Background: Psoriasis is a chronic inflammatory skin disease associated with multiple systemic comorbidities. Patients exhibit considerable individual variability in response to systemic therapies, making treatment outcomes and adverse reactions difficult to predict. Traditional Chinese Medicine (TCM) constitution theory may explain this variability, but prospective validation is lacking.
Colorectal cancer organoids: a developmental trajectory from Matrigel embedding to AI-empowered precision medicine
Abstract The high heterogeneity and complex microenvironment of colorectal cancer (CRC) represent critical bottlenecks contributing to treatment resistance and clinical translation failure, and the iterative development of organoid technology provides a key driving force for precision oncology.
Expedient Modular Assembling of Chiral η6-Benzene Ligands: Empowering Ruthenium-Catalyzed Asymmetric C–H Activation
Abstract Click to copy section linkSection link copied! Transition metal-catalyzed asymmetric C–H activation is an atom- and step-economical route to chiral molecules, yet the development of cost-effective ruthenium catalysts lags far behind that of palladium and rhodium. Notably, chiral η6-benzene ruthenium catalysts (BenRu) provide an effective tool to tackle the ruthenium-catalyzed asymmetric C–H activation. However, the existing catalysts suffer from tedious synthesis and limited tunability.
Satellite altimetry reveals intensifying global river water level variability - Nature Communications
Abstract River water levels (RWLs) are fundamental to hydrology, water resource management, and disaster mitigation, yet the majority of the world’s rivers remain ungauged. Here, using 46,993 virtual stations from Sentinel-3A/B altimetry (2016‒2024), we present a global assessment of RWL variability.
Declining ocean greenness and phytoplankton blooms in low to mid-latitudes under a warming climate
Abstract Marine phytoplankton are crucial to oceanic ecosystems, yet trends in their activity, monitored through chlorophyll a, remain uncertain due to observational limitations. We generated an ocean chlorophyll a dataset (2001 to 2023) across low to mid-latitudes (45°N to 45°S) using multisource data and a deep learning approach.
Extreme and compound events in lakes - Nature Reviews Earth & Environment
Abstract Extreme and compound events disrupt lake ecosystems worldwide, with their frequency, intensity and duration increasing in response to climate change. In this Review we outline evidence of the occurrence, drivers and impact of extreme and compound events in lakes.
Unprecedented large-scale aquifer recovery through human intervention - Nature Communications
Abstract Groundwater depletion is a critical global challenge, particularly in intensively cultivated drylands, with few documented cases of successful recovery. Here, we report a striking reversal of long-term groundwater decline in the North China Plain, one of the world’s most severely depleted aquifers.
Global dominance of seasonality in shaping lake-surface-extent dynamics - Nature
Abstract Lakes are crucial for ecosystems1, greenhouse gas emissions2 and water resources3, yet their surface-extent dynamics, particularly seasonality, remain poorly understood at continental to global scales owing to limitations in satellite observations4,5. Although previous studies have focused on long-term changes6,7,8, comprehensive assessments of seasonality have been constrained by trade-offs between spatial resolution and temporal resolution in single-source satellite data.
Tamgram: A Frontend for Large-scale Protocol Modeling in Tamarin
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CD4+CD57+ senescent T cells as promoters of systemic lupus erythematosus pathogenesis and the therapeutic potential of senolytic BCL‐2 inhibitor
Conflict of interest The authors declare no commercial or financial conflict of interest. Supporting Information Filename Description eji5714-sup-0001-SuppMat.pdf827.6 KB Supporting information References 1, Autoimmunity and organ damage in systemic lupus erythematosus. Nat. Immunol. 2020. 21: 605–614. 2, and , Genetic susceptibility to SLE: recent progress from GWAS. J. Autoimmun. 2013. 41: 25–33. 3, Systemic lupus erythematosus. N. Engl. J. Med. 2011. 365: 2110–2121.
Grassland Greening and Water Resource Availability May Coexist in a Warming Climate in Northern China and the Tibetan Plateau
1 Introduction Grasslands account for approximately 30% of the global land surface (Lemaire et al., 2011) and possess critical ecosystem functions (e.g., regulating water cycles, storing carbon, controlling erosion, and providing livelihoods for living things) (Bengtsson et al., 2019). In China, nearly 40% of the land is covered by grasslands, 78% of which is distributed in Northern China and the Tibetan Plateau (NCTP) (Chen & Wang, 2000).
VBA自定义函数TEXTJOIN CONCAT FILTER EVALUATE
VBA是Office自带的，无需再安装。若使用WPS，需安装VBA插件；以下是实现代码。Office或WPS电脑端用户须已安装VBA且必须启用宏才能使用。 工作表TEXTJOIN函数实现代码： Function TEXTJOIN(ByVal 分隔符, ByVal 忽略空值1不忽略0, ParamArray 字符串()) '每个参数都允许传入（1个字符串|N个单元格区域|1-60维数组），根据第二参数来输出，结果允许是1个字符串或一维数组或二维数组。（暂不支持输出≥3维的数组，请原谅我太懒） On Error Resume Next Dim 一维下标 As Long, 一维上标 As Long, 二维下标 As Long, 二维上标 As Long, di As Long, 计数 As Long Dim 忽略字符串空值 As Variant, 不忽略字符串空值 As Variant, 忽略or不忽略 As Boolean, 非数组 As Boolean Dim 子串 As Variant, 子串1 As Variant, DicPut() ' As Variant If...
Widening educational inequalities in mortality in more recent birth cohorts: a study of 14 European countries
Methods Comparative mortality figures (CMF) were used to measure mortality difference between calendar periods (CMF) and between birth cohorts (cohort CMF, CCMF), based on direct standardisation22 (details in online appendix 4). Simply put, CMFs are calculated for each combination of country, sex, level of education and cause of death as follows: and As standard population, we used pooled population of all countries, all educational groups and all calendar periods, separate for men and women.
Non-monotonic changes in Asian Water Towers’ streamflow at increasing warming levels - Nature Communications
Abstract Previous projections show consistent increases in river flows of Asian Water Towers under future climate change. Here we find non-monotonic changes in river flows for seven major rivers originating from the Tibetan Plateau at the warming levels of 1.5 °C, 2.0 °C, and 3.0 °C based on an observation-constrained hydrological model.
Global water resources and the role of groundwater in a resilient water future - Nature Reviews Earth & Environment
Abstract Water is a critical resource, but ensuring its availability faces challenges from climate extremes and human intervention. In this Review, we evaluate the current and historical evolution of water resources, considering surface water and groundwater as a single, interconnected resource. Total water storage trends have varied across regions over the past century.
Reconstructed eight-century streamflow in the Tibetan Plateau reveals contrasting regional variability and strong nonstationarity - Nature Communications
Abstract Short instrumental streamflow records in the South and East Tibetan Plateau (SETP) limit understanding of the full range and long-term variability in streamflow, which could greatly impact freshwater resources for about one billion people downstream. Here we reconstruct eight centuries (1200−2012 C.E.) of annual streamflow from the Monsoon Asia Drought Atlas in five headwater regions across the SETP.
Climate change threatens terrestrial water storage over the Tibetan Plateau - Nature Climate Change
Abstract Terrestrial water storage (TWS) over the Tibetan Plateau, a major global water tower, is crucial in determining water transport and availability to a large downstream Asian population. Climate change impacts on historical and future TWS changes, however, are not well quantified.
Health inequities as measured by the EQ-5D-5L during COVID-19: Results from New York in healthy and diseased persons
HRQoL For all respondents, mean (SD) EQ-5D-5L index, LSS, and EQ VAS were 0.82(0.26), 7.5(3.4), and 79.3(17.4), respectively. Mean EQ outcome scores varied by levels of response in each characteristic category (Table 2). Almost every factor relating to a more disadvantaged position showed a worse score in HRQoL, except for age. Scores of HRQoL improved with higher age category. Non-Hispanic whites and non-Hispanic Asians had the best score in HRQoL compared to other racial/ethnic groups.
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