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Articles

Future flood risk concentration for residents near small rivers across the USA

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By Ruijie Jiang, HUI LU, Deliang Chen, Kun Yang, Dai Yamazaki, Hiroshi Chô, Gang Zhao, Jiahua Wei, Fuqiang Tian, Dabo Guan
| Nature Verified
Abstract Climate change and socioeconomic development are projected to increase global fluvial flood risk. Most studies have focused on large rivers or aggregated regional assessments, leaving limited understanding of how flood risk varies across river sizes.
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Towards the construction of a virtual yeast

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By Liujia Qian, Zizhuo Zhou, Peijie Zhou, Zhen Dong, Xudong Zhang, Zhangyang Gao, Siqi Sun, Kevin Roy, Shuaiyao Wang, Nicola Zamboni, Charles Boone, Michael Costanzo, Jianzhe Li, Gianni Liti, Jia-Xing Yue, Markus Ralser, Evan Williams, Mattia Zampieri, Heng Jiang, Tailin Wu, Yalin Wang, Feiran Li, Joseph Schacherer, Rui Sun, Zhaoxing Li, Yaming Deng, Yi Chen, Zhiping Xie, Huiqiang Lou, Xiaowen Wang, Linhai Xie, Liangyi Chen, Kai Lei, George Rosenberger, Xue Cai, Yingrui Wang, Qi Xiao, Huaizong Shen, Gaowen Liu, Lei Ma, Brenda Andrews, HUI LU, Kiryl D. Piatkevich, Yi Zhu, Lei Bai, Yizhi Cai, Yuping Chen, Ge Gao, Fuchu He, Luonan Chen, Stan Z Li, Hongwu Ma, Liang Qiao, Lars M. Steinmetz, Tang K. Tang, Xiaofan Zhang, JING YANG, Yifan Yang, Kaicheng Yu, Jianyang Zeng, Yefeng Zheng, Bowen Zhou, Tiannan Guo, Zhenwu Dai, Leihan Tang
| Nature Verified
Abstract To advance the computational simulation of cellular life, we propose a virtual yeast, an artificial intelligence (AI)-driven agent that models eukaryotic cellular behaviours by integrating multimodal biological data, mechanistic reasoning and active experimentation using Saccharomyces cerevisiae as a genetically tractable and data-rich model system.
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Bispecific antibody engineered extracellular vesicles redirect T cells to prevent postoperative epidural fibrosis

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By Shanwei Ye, qian Xu, Yong Xu, HUI LU, Zhenfeng Liu, Jianfeng Guo, Yichuan Li, Wei Qing Wang, Jun Ran, Xiaohua Zhu, Dongling Zhu, Wei Wu, Zechuan Yang, Feng LI, Lugui Qiu, Ellen Puré, Vijay G. Bhoj, Liang Huang, Wei Xiong, Zheng Zhang, Shiqi Gu
| Nature Verified
Abstract Epidural fibrosis (EF) is a frequent and debilitating complication that impairs recovery following spinal surgery, yet effective targeted therapies are lacking. Here we observe enrichment of FAP⁺ fibroblasts at surgical sites in patients after laminectomy. To therapeutically target this subset, we develop bispecific antibody–decorated extracellular vesicles (BsAb EVs), which redirect endogenous T cells to eliminate FAP⁺ fibroblasts in situ.
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