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Diala Abd Rabbo

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Articles

The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

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By Sabelo Lukhele, Diala Abd Rabbo, Mengdi Guo, Jian Shen
| Cell Press Verified
• None BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells. : • None Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system. : • None Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2. : • None Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers.
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