Diethard Monbaliu

Results To complete the lead optimization of FXT-001 (Figure 1A), we conducted comprehensive absorption, distribution, metabolism, and excretion (ADME) and safety profiling. FXT-001 potently inhibited ferroptotic cell death in the nanomolar range, displayed high thermodynamic solubility across a broad pH range (pH 2–7), and showed moderate lipophilicity based on both experimental LogD7.4 and predicted calculated logP (cLogP) values (Figure 1B).

Abstract To alleviate the persistent shortage of donor livers, high-risk liver grafts are increasingly being considered for liver transplantation. Conventional preservation with static cold storage falls short in protecting these high-risk livers from ischemia–reperfusion injury, as evident from higher rates of post-transplant complications such as early allograft dysfunction and ischemic cholangiopathy.

Background The global shortage of suitable donor livers for transplantation has prompted efforts to expand the donor pool by using extended criteria donors. Machine preservation technology has shown promise in optimizing graft preservation and improving logistics. Additionally, it holds potential for organ repair, regeneration, therapeutic applications during extended preservation periods, and enhancing organ allocation.