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Dimitri M. Kullmann on Muck Rack

Dimitri M. Kullmann

As seen in: Nature, Wiley Online Library, MDPI, The Conversation, Agenda (World Economic Forum), BioRxiv, Brain, ScienceAlert, News Lanes, BioCentury and
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Articles

Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent

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By Sahil Patel, Luiz Silva, Olivia Goff, Amy W. Richardson, Jesse I. Mobbs, Hariprasad Venugopal, David M. Thal, Dimitri M. Kullmann, Steven O. Devenish, Laura V. Ussingkær
| Nature Verified
Abstract Chemogenetics allows the controllable manipulation of brain circuits upon delivery of a selective activating ligand, and has been invaluable in dissecting brain circuits underlying many behaviours. The Gαi/o-coupled designer muscarinic receptor hM4Di is an especially versatile tool for on-demand inhibition, and has proven effective not only in fundamental neuroscience but also as a therapeutic transgene in preclinical models of epilepsy and other CNS disorders.
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Deciphering temporal gene expression dynamics during epilepsy development using a rat model of focal neocortical epilepsy

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By Bao-Luen Chang, Matthew Walker, Dimitri M. Kullmann, Stephanie Schorge
| Wiley Online Library Verified
Corresponding Author Bao-Luen Chang Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center, Taoyuan, Taiwan School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan Correspondence Bao-Luen Chang and Stephanie Schorge, Department of...
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Supralinear dendritic integration in murine dendrite-targeting interneurons

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By Simonas Griesius, Amy W. Richardson, Dimitri M. Kullmann
| BioRxiv
Abstract Non-linear summation of synaptic inputs to the dendrites of pyramidal neurons has been proposed to increase the computation capacity of neurons through coincidence detection, signal amplification, and additional logic operations such as XOR. Supralinear dendritic integration has been documented extensively in principal neurons, mediated by several voltage-dependent conductances.
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